Azithromycin for children: instructions for use. Effective universal antibiotic Azithromycin (instruction from ingestion) Azithromycin 250 mg

Azithromycin is a current synthetic antibacterial drug of the azalide subclass (macrolide group), which has a wide range of effects on pathogenic microflora and may affect bacteriostatic disease.

Vіn zastosovuєtsya in case of ignition-infectious lesions, especially in depressions, if the penicillin series does not take into account the bacterial flora.

Diuchoy (active) rechovina є azithromycin dihydrate, chemically from the stage of some attack: 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A.

Azithromycin is known to easily penetrate into all tissue organs. Tse reaches the heart of the active soaking of medicinal speech from the intestines into the blood. The fluffy speech is not afraid of sour mediums and it is widely distributed in fats.

Azithromycin dihydrate - speech of prolonged action, moreover, a one-time application, especially in a loading dose, preserves its presence in the organism up to 6 days. After taking azithromycin, literally in 2 years, the maximum concentration of intoxicating speech in the body is observed, which allows reaching a high therapeutic effect after the first doses of liquor.

For rahunok tsієї osobennostі, drug away glaring serious infections in short courses(within 3 to 5 days), moreover, with zruchny dosing - 1 dose per doba. Zavdyaki azithromycin having taken away the great popularity among children in practice and zastosovuetsya with various infections in the younger generation.

Formulation and dosing of azithromycin for children

I look back at those that azithromycin is an exhausting zasib of bacteria, in case of mild illness, vicoristovate is not recommended. Only for the obviousness of special indications of yoga are “connected” like a shock score. For children, azithromycin is prescribed in tablets of 125 and 250 mg, as well as capsules of 250 mg official instructions sodo zastosuvannya zasobu). One blister contains 6 tablets and capsules.

For ease of use, there is one more form of azithromycin for children - a suspension (syrup), but not 250 mg is indicated on the packages, as in the tablet form, but the following information is given: 100 mg / 5 ml or 200 mg / 5 ml. For example, in order to take a suspension at a dose of 250 mg, it is necessary to give a child 12.5 ml once (at a dose on the package of 100 mg / 5 ml).

The dosing of the drug and the validity of taking it means less drug. No matter how antibacterial the disease is, it does not affect the independent vikoristanny, especially in children.

The dose of azithromycin 125-250 mg is prescribed for weight not less than 45 kg; For children with body weight up to 45 kg, the drug should be given as a dose of 10 mg/kg (taken 1 time per doba).

The drug is taken after meals (for a year or two years after). The hour of living the likiv is guilty of buti fixing, for example, about the 11th wound. Do not open the tablet or the capsule and wash it down with water.

Instructions for administering azithromycin for children tell about the method of taking all forms of the drug, ale The most popular are capsules of 250 mg.. Їx is easy to forge, because stench kovzayut, and mine is not overwhelmed unacceptable perceptions like taking pills. Solid forms of azithromycin are already present in mature children, so they can easily be taken correctly.

important ! For children under 6 months of age, azithromycin is not indicated for a combination of high dysmotility, the appearance of sudomny reactions and mucosal-intestinal lesions (up to bleeding).

The price for azithromycin 250 varies between 50-90 rubles and more, fallow from pharmacological firms, if you want to be aware of social propositions, for example, from the firm Vertex (Russia) - 32 rubles. Analogues of azithromycin may increase the price. The amount of honey (Teva, Israel), the largest known analogue, is in the range of 350 rubles.

Indications before ingestion of azithromycin

The drug is prescribed for the onset of pathological processes:

• sinusitis (injury to the sinuses);
• tonsillitis (gostrih and recurrent forms);
• pharyngitis;
• bronchitis;
• tracheitis;
• pleurisy (in cob stages of ailment);
• pneumonia;
• erysipelas;
• infectious dermatoses;
• furunculosis;
• scarlet fever;
• infections of the organs of the body;
• impetigo;
• in complex schemes, the treatment of ShKT;
• ailment Lyme (tick-borne boreliosis).

In order for the treatment to be effective, the next step was to establish a bacterial count on the microflora with an antibioticogram. Danish analysis to determine the ailment of the ailment and to help establish whether azithromycin is suitable for a particular patient. For example, in case of angina, take a swab from the area of ​​the affected tonsils.

The negative moment is those who prepare the bakposiv for 5-10 days, and the ailment is rich, and we don’t check for a long time. To that, as a rule, they should win, and then they will assign a blind mark. If the antibiotic is not used, then with the review of the results of the smear, it will be possible to accurately inject the sensitive drug to pathogenic microflora.

You can get to know other effective faces in the undead.

Contraindications and side effects

Azithromycin, as well as all antibacterial agents, may be a number of small doses it is not allowed to zastosuvannya during the offensive camps:

• intolerance to macrolides;
• arrhythmias (important forms);
• scalability to allergic reactions;
• myasthenia;
• severe liver disease and nirok;
• week to 6 months.

Side reactions can be seen:

• carry;
• vomiting;
• persistent tedium;
• zamorochennya;
• bіl or rіz near the stomach;
• flatulence;
• tachycardia;
• vіdmovi vіd їzhі;
• visipan on the shkіrі;
• drativity;
• sleep disturbance;
• disruption of biochemical blood tests (often for overdose).

The appearance of pronounced side effects will require a negative administration of the drug.

Can you accept antihistamine drug(Erius, claritin, loratadine). Choose one of these drugs, the drug is prescribed for the "prescription" of antibiotics, far ahead of unsafe symptoms. If so, if there is a reaction to an antibiotic, then it will pass in the most innocent form.

How to take azithromycin 250 correctly?

The medicinal preparation is guilty of keeping far away from children and sleepy light. The recommended storage temperature is 15-25 °C. The term of affinity for azithromycin indications on the packaging and to become 2-3 rocks, fallow in the virobnik.

Keep in mind that azithromycin 250 tablets and capsules will be taken for a long time, because the skin bead is protected by a blister, and the syrup (suspension) in the face looks like it is dry, so save no more than 10 deb.

Azithromycin analogs

Analogues can zbіgatisya behind the fluffy speech or the mechanism of diї. Also, we provide a list of analogs, if you have azithromycin in your warehouse:

• chemomycin;
• sumamed;
• clubax;
• sumamox;
• azitrox;
• zitrocin;
• Azicide;
• sumaclide;
• zitrolide;
• others.

You can also replace azithromycin, as the drug itself does not appear to be suitable. All analogues have their own price, and there are three times more for the price of azithromycin.

For a similar mechanism, the following preparations are suitable:

• clarithromycin;
• erythromycin;
• lecoclair;
• arvicin;
• spiramycin;
• macrofoams;
• rovamycin;
• fromelide;
• others.

Analogues, recommendations, side effects of Azithromycin

Notes on the intake of azithromycin 250

Before trying azithromycin 250, the fathers resolutely read the instructions for zastosuvannya for children, vodguki, that they analyze, why not to harm the antibiotic to the child? Such a pidkhid, no doubt, true and meritorious. It's a great pity, deyak unfortunate doctors practice using azithromycin not for recognition, if you can get away with ailment and light antibiotics.

Obviously, the effect of azithromycin will be blissful, but at the same time, it will be similar to folding infections, as the body will not take a strong antibiotic in simple forms of ailment. It’s worth to take a serious moment from the likuvanni and the father is guilty about the nobility. Trust ale, revise. If you have any doubts about sumniviv - take a consultation in another fakhivtsya.

And at the same time, let's get to know the fathers' notes, they took them from the listing of the coristuvachs from the other forums.

Nastya

Daughter (14 years old) is constantly ill with HPV, and, unfortunately, the ailment is often aggravated by tracheitis or bronchitis, moreover, the aggravation after the virus comes quickly. Recently, they got very sick. Pediatrician prescribed Augmentin, ACC, erespal in syrup. The result was practically not bulo, wheezing went down lower. Donka, if she coughed, then I, not to the doctor, it was clear that the breath was weakened, and the cough was in the middle of the moon.

The antibiotic was replaced with azithromycin 250. After the first tablet, the temperature returned to normal. And in three days the child was healthy. Usogo three tablets and the same results. Thanks for the merit at a high rating, and I give it.

Valentine

The drug prescribed amoxiclav and recognized sumamed (a total of 5 tablets). I want to get ahead, sumamed is an analogue of azithromycin, but it means more expensive. The pharmacist told me the information, I really doubted a little, but I still took azithromycin. About 15:00 we took the first pigulka. Vranci twisted her throat and pleased the result: poured 50% off. We drank all the piguki. Potim drank 10 days Narina (kefir against dysbacteriosis) for prevention. Heavy angina azithromycin podolav with a bang.

Natalia

Sinovі was 10 years old, if you got a serious cold. Strongly coughing, sweating, the temperature was close to 37.3 degrees. Likar, having listened to the child, pointed out that the dyhanna is zhorstka, weakly, it is similar to right-sided dry pleurisy. On the first day, it was recognized: azithromycin 250, and on the next day they took a smaller dose - 125 mg each. The child quickly went to the correction room.

After a deaky hour, the synovial roiled a fluorographic sign, and the doctor the radiologist paid attention to those who “soldered” the sinus - that does not mean that if you had pleurisy. Later, azithromycin added, and at that hour we managed without injections. Miracle antibiotic!

Janina

The axis is written less positively, but in me the message is less. Menі 24 years, no longer a child, an ale dose of the drug azithromycin was prescribed in a child dosing - 250 mg. It's just that my vaga became 49 kg and that was given such a dose. They exulted tracheobronchitis. Skarzhilas on cough, thick sputum, ass, mlyavist that headache.

Bronchitis proishov, but a day later I received it the rest of the walk(p'yaty behind the rachunk) a motor-like visip began to appear all over the body. There was not a single bite on the faces of that hands. They put me on a diet, prescribed karsil, holosas and erius. Ale, unimportantly for all the whole likuvannya hanging out went even more correctly. Only in two months the shkir was completely cleared.

They didn’t know the reasons for such a phenomenon, but the immunologist’s comment was that the immune system is weak and the liver is rotten cleansed, although the results of blood and ultrasound pathology with the liver were not known. The axis is such my dosvid likuvannya azithromycin.

Oleksandra

She fell ill at the dacha. Undead, fever, and then a sickening cough. Moreover, I infected my daughter, shvidshe for everything viral infection"sprayed". It was necessary to go to work on Mondays, but the chief by phone clearly gave an understanding that I could be ill for only three days, otherwise I would know the change. Vryatuvav lishe sumamed is an analogue of azithromycin.

Donka developed a strong bronchitis, and our dilnichna also pleased him to drink sumamed less for a child dosing. Moreover, my daughter passed pus eel visip, with which already another river we fought Mabut, a whisker is small infectious disease. I've been more satisfied with the drug, I can say more, that I haven't experienced such a mitigating effect with antibiotics before.

Azithromycin is a highly effective antibacterial agent due to a relatively low price, a three-year period of administration and a low number of side effects (not more than 2%). The antibiotic occupies a leading position regarding the frequency of prescribing in treating child infections and showing the results of therapy.

Registration number: LSR-003652/07-010616
Trade name: Azithromycin
International non-proprietary name (INN): azithromycin
Pharmaceutical form: capsules
warehouse
Active speech: azithromycin dihydrate - 265.3 mg; in reversal to active speech (azithromycin) - 250.0 mg.
Additional speech: microcrystalline cellulose - 104.7 mg, corn starch - 28.0 mg, low molecular weight poudone - 6.0 mg, magnesium stearate - 6.0 mg.
Warehouse for the capsule body: titanium dioxide - 1.0000%, barvnik zhovtium oxide - 0.0733%, gelatin - up to 100%.
Warehouse of the capsule cap: titanium dioxide - 1.0000%, barvnik of the saliva yellow oxide - 0.0733%, gelatin - up to 100%.
Description
Capsule No. 0. The body and the cap of the capsule are yellow, light brown in color, opaque.
Vmist capsules - powder of white or white light yellow with a slightly yellowish color.

Pharmacotherapeutic group: antibiotic-azalide.
ATX code: J01FA10

Pharmacological activity

Pharmacodynamics
Broad-spectrum antibacterial zasib di, azalid, di bacteriostatically. Linking from the 50S subunit of ribosomes, inhibiting the peptide translocase at the stage of translation, inhibiting protein synthesis, increasing the growth of bacteria, high concentrations may have a bactericidal effect. Die on the posture of internal health workers. Active level of gram-positive microorganisms: Streptococcus spp. (group C, F and G, cream resistant to erythromycin), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis, Staphylococcus aureus; Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonorrhoeae and Gar; some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; as well as internal pathogens: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium avium complex, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdorferi. Inactive for Gram-positive bacteria resistant to erythromycin.

Pharmacokinetics
Absorption - high, acid-resistant, lipophilic. Bioavailability after a single dose of 0.5 g - 37% (the effect of "first passage" through the liver), the maximum concentration in plasma after oral administration of 0.5 g - 0.4 mg / l, the period of reaching the maximum concentration in blood plasma - 2, 5-2.9 year; in tissues and cells, the concentration in 10-50 times in the body, lower in blood syrorrhea, total rose - 31.1 l / kg. It is easy to pass histohematic barriers. The good penetrates at the distal path, the sechostate organs and tissues, at the front ridge, at the skin soft fabrics; accumulates medium with low pH, in lysosomes (which is especially important for the eradication of intracellular rotting diseases). It is also transported by phagocytes, polymorphonuclear leukocytes and macrophages. Penetrates through clitin membranes and creates high concentrations in them. The concentration in the middle of the infection is significantly higher (by 24-34%), lower in healthy tissues, and correlates with the severity of the ignition rash. It is taken in effective concentrations for 5-7 days after the remaining dose. Relationship with plasma proteins - 7-50% (backward proportional concentration in the blood). The liver is demethylated, the metabolites that are metabolized are not active. Metabolism takes the role of isoenzyme CYP3A4, CYP3A5, CYP3A7, an inhibitor of these wines. Plasma clearance - 630 ml / min. The period of application between 8 and 24 years after the receptionist is 14-20 years, the period of application in the interval from 24 to 72 years is 41 years. 50% are shown with a lively look, 6% - with nirks. Taking it significantly changes the pharmacokinetics (in the fall as a medicinal form): capsules - the maximum concentration in blood plasma decreases (by 52%). In summer people (65-85 years) pharmacokinetic parameters do not change, in women the maximum concentration in plasma increases (by 30-50%), in children in 1-5 years the maximum plasma concentration decreases, the period of administration.

Indication before zastosuvannya

Infectious inflammation caused by microorganisms sensitive to the drug: infections of the upper respiratory tract and ENT organs (pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media); scarlet fever; infections of the lower respiratory tract (pneumonia (caused by atypical diseases), bronchitis); infections of skins and soft tissues (beshiha, impetigo, other infections of dermatosis); infections of the sieve paths (gonorrheal and non-gonorrheal urethritis, cervicitis); Lyme ailment (on the cob stage - erythema migrans), virazova ailment and duodenum 12, associated with Helicobacter pylori (at the warehouse of combined therapy).

Contraindication

Hypersensitivity (including up to other macrolides), severe liver/nirk deficiency, lactation period, children up to 12 years of age (with body weight less than 45 kg).
Protective: arrhythmia (possible slunar arrhythmias and prolonged Q-T interval), children with impaired liver function or vagity.
Zastosuvannya with vagity during lactation: you can zastosovuvatisya in quiet depressions, if the measles in this zastosuvannya significantly overwhelm the risk, which you always have when vikoristannі be-such a drug protyag vagity. If necessary, the drug should be prescribed during lactation, then breastfeeding should be given.

Method of stosuvannya that dose

Vseredinu, 1 year before or after 2 years after that, go 1 time to doba.
We grow older in case of infections of the upper and lower respiratory tract - 500 mg per doba for 1 dose for 3 days (course dose - 1500 mg). In case of skin and soft tissue infections - 1000 mg per doba on the first day for 1 dose, 500 mg per doba daily from 2 to 5 days (course dose - 3000 mg). In case of acute infections of the sechostatic organs (uncomfortable urethritis or cervicitis) - a single dose of 1 g. In case of Lyme disease (boreliosis) for treatment of stage I (erythema migrans) - 1000 mg on the first day and 500 mg on the first day from 2 to 5 days (course dose - 3 G). When virazkovy ailment of the duct and 12-colon intestine, associated with Helicobacter pylori, - 1 g per extract for 3 days at the warehouse of combined anti-Helicobacter pylori therapy.
For children over 12 years of age (with a body weight of over 45 kg) in case of infections of the upper and lower dycal passages, skins and soft tissues, 500 mg is prescribed 1 time per doba for 3 days.
When treating erythema migrans in children (over 12 years of age), the drug is prescribed once a day at a dose of 1000 mg on the first day and 500 mg each day 2 to 5.

Pobichna diya

From the side of the intestinal tract: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% and less - flatulence, vomiting, melena, cholestatic zhovtyanitsya, increased activity of "hepatic" transaminases; in children - constipation, decreased appetite, gastritis; candidiasis of the mucous membrane of the mouth empty, change in taste (1% and less).
From the side of the cardiovascular system: heartbeat, pain in the chest cavity (1% and less).
3 side nervous system: confusion, bіl head, drowsiness; in children - headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less).
From the side of the sechostatic system, vaginal candidiasis, nephritis (1% and less).
Allergic reactions: hanging, kropyvyanka, swollen shkir, angioedema, conjunctivitis in children.
Others: asthenia, photosensitivity.

Overdose

Symptoms: severe tedium, timchasova loss of hearing, vomiting, diarrhea.
Treatment: washing the drain, symptomatic therapy.

Interaction with other medical care

Antacids (aluminum and magnesium), ethanol and even increase and decrease the absorption of azithromycin.
With the total recognition of warfarin and azithromycin (at the highest doses), there was no change in the prothrombin hour, however, it is safe, but with the interaction of macrolides and warfarin, it is possible to increase the anticoagulant effect, patients need a permanent control of the prothrombin hour.
Increases the concentration of digoxin due to the weakening of the inactivation of the intestinal flora.
Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia).
Triazolam: decreased clearance and increased pharmacological science triazolam.
Upovіlnyuє vivedennya that pіdvischuє kontsentratsіyu in plazmі that toksichnіst cycloserine, indirect antikoagulyantіv, metilprednіzolonu, felodipіnu and takozh lіkarskih zasobіv scho pіddayutsya mіkrosomalnomu oxidation (karbamazepіn, terfenadine, cyclosporine, geksobarbіtal, alkaloїdi, zasobi, teofіlіn that іn. (Ksantinovі pohіdnі), for Rachunok inhibition of microsomal oxidation in hepatocytes by azithromycin.
Lincosamides weaken, and tetracycline and chloramphenicol increase the effectiveness of azithromycin.

especially vkazіvki

Don't accept chi from the hedgehog.
At the time of missing a dose, a dose was missed, the next dose was taken earlier, and the next - at an interval of 24 years.
It is necessary to take a break for 2 years with a one-hour stagnation of antacids.
After seeing the exaltation of hypersensitivity in some patients, they can be saved, which will help specific therapy under the doctor's eye.

Release form
Capsules 250 mg.
3, 6 capsules in a contour middle pack with polyvinyl chloride and aluminum foil lacquered.
3, 6, 12, 18, 24, 30, 36, 42, 48, 54 or 60 capsules per can of polyethylene terephthalate or polymer cans for medicinal purposes.
One jar or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 contour middle packs at once with instructions for filling is placed next to the cardboard packaging (pack).

Wash away the savings
Protect the protected from light at a temperature not higher than 25 °C.
Take care of the place inaccessible to children.

In this article, you can read the instructions from the zastosuvannya medicinal preparation Azithromycin. Presented are reviews on the site - supportive of their faces, as well as thoughts of doctors on how to win Azithromycin from their practice. Great prohannya actively add your opinions about the drug: they helped or didn’t help people get sick, as they were afraid of aggravating that side effect, which may not have been declared by the doctor in the annotation. Analogues of Azithromycin for the presence of obvious structural analogues. Witchcraft for the treatment of angina, pneumonia and other infections in adults, children, and also with vaccinia and breastfeeding.

Azithromycin- Broad spectrum antibiotic. It is a representative of a subgroup of macrolide antibiotics - azalides, and bacteriostatically. When mixed in the middle of the fire, high concentrations may cause bactericidal activity.

Die on the posture of internal health workers. Gram-positive and gram-negative microorganisms are susceptible to azithromycin; anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; as well as Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdorferi. Azithromycin is not active against Gram-positive bacteria resistant to erythromycin.

Also active is Toxoplasma gondii.

Pharmacokinetics

Azithromycin is easily absorbed from the mucosal-intestinal tract, which is bound by its acidic stability and lipophilicity. Azithromycin penetrates well in the dichal passage, the organs and tissues of the urogenital tract (zocrema in the anterior fold), in the skin and soft tissues. The ability of azithromycin to accumulate more importantly in lysosomes is especially important for the elimination of internal cellular disorders. It has been shown that phagocytes deliver azithromycin to the site of infection localization, and that they deviate in the process of phagocytosis. The concentration of azithromycin in the middle of infection is significantly higher, lower in healthy tissues (by 24-34% on average) and correlative with the degree of ignition swelling. Regardless of the high concentration in phagocytes, azithromycin does not directly affect their function. Azithromycin is kept at bactericidal concentrations for 5-7 days after taking the remaining dose, which allowed for short (3-day and 5-day) courses of treatment. The liver is demethylated, the metabolites that are metabolized are not active. 50% are shown with a lively look, 6% - with nirkami.

Indication

Infectious-flammable disease caused by micro-organisms sensitive to the drug:

• infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media);
• scarlet fever;
• infections of the lower respiratory tracts (including those caused by atypical diseases);
• infections of skins and soft tissues (beshiha, impetigo, other infections of dermatosis);
• infections of the urogenital tract (uncomplicated urethritis and/or cervicitis);
• Lyme disease (boreliosis); for the treatment of the cob stage (erythema migrans);
• infection of the duodenum and twelve colonies, associated with Heliobactcr pylori (in combination therapy).

Form release

Tablets coated with a plaited shell 250 mg and 500 mg.

Capsules 250 mg and 500 mg.

Instructions for stopping and dosing

Vseredinu, 1 year before or after 2 years after that, go 1 time to doba.

We grow older in case of infections of the upper and lower respiratory tract - 500 mg per doba for 1 dose for 3 days (course dose - 1.5 g).

In case of infections of skin and soft tissues - 1000 mg per doba on the first day for 1 dose, 500 mg per doba from day 2 to 5 (course dose - 3 g).

In case of acute infections of the sechostatic organs (uncomfortable urethritis and cervicitis) - a single dose of 1000 mg.

With Lyme disease (boreliosis) for treatment of stage 1 (erythema migrans) - 1000 mg on the first day and 500 mg every other day from 2 to 5 days (course dose - 3 g).

In case of viral ailment of the duodenum and duodenal ulcer, associated with Helicobacter pylori - 1 g per day for 3 days at the warehouse of combined anti-Helicobacter pylori therapy. Children over 12 years of age (with a body weight of 50 kg and more) with infections of the upper and lower dychal passages, skins and soft tissues - 500 mg 1 time per doba for 3 days.

When clearing erythema migrans in children, the dose is 1000 mg on the first day and 500 mg daily on days 2 to 5.

Pobichna diya

• diarrhea;
• boredom;
• bіl in the stomach;
• dyspepsia (flatulence, vomiting);
• constipation;
• anorexia;
• change of taste;
• candidiasis of the mucous membrane of the oral stool;
• heartbeat;
• bіl thoracic cleft;
• zamorochennya;
• head bіl;
• drowsiness;
• neurosis;
• sleep disturbance;
• vaginal candidiasis;
• seep;
• pobryak Quincke;
• Sverbіzh skiri;
• kropivyanka;
• conjunctivitis;
• increased stubbornness;
• photosensitivity.

Contraindication

• liver and/or liver failure;
• lactation period;
• child age up to 12 years;
• hypersensitivity (including to other macrolides).

Congestion with vagity and breastfeeding

You can zastosovuvatisya under the hour of vagity, if the measles in the yogo zastosuvannya signifi cantly change the rizik, which you have to use when vikoristannі be-such a drug protyag vaginosti.

If it is necessary to recognize the drug during lactation, it is necessary to change the nutritional status of breastfeeding.

especially vkazіvki

At the time of missing a dose, the next dose was missed, and the next dose was taken earlier, and in the next - with an interval at 24 years.

It is necessary to take a break at 2 years of age with an one-hour stagnation of antacids. After seeing the exaltation of hypersensitivity in some patients, they can be saved, which will help specific therapy under the doctor's eye.

Medical interaction

Antacids (aluminum and magnesium), ethanol (alcohol) and even improve and reduce absorption. With the total recognition of warfarin and azithromycin (at the highest doses), there was no change in the prothrombin hour, however, it is safe, but with the interaction of macrolides and warfarin, it is possible to increase the anticoagulant effect, patients need a permanent control of the prothrombin hour.

Digoxin: increased concentration of digoxin.

Ergotamine and dihydroergotamine: increased toxic effects (vasospasm, dysesthesia).

Triazolam: decreased clearance and increased pharmacological action of triazolam. Upovіlnyuє vivedennya that pіdvischuє kontsentratsіyu in plazmі that toksichnіst cycloserine, indirect antikoagulyantіv, metilprednіzolonu, felodipіnu and takozh lіkarskih zasobіv scho pіddayutsya mіkrosomalnomu oxidation (karbamazepіn, terfenadine, cyclosporine, hex-barbіtal, alkaloїdi, gіpoglіkemіchnі zasobi, teofіlіn that INSHI ksantinovі pohіdnі) - for rachunok inhibition of microsomal oxidation in hepatocytes by azithromycin.

Lincosamines weaken the effectiveness, tetracycline and chloramphenicol - strengthen.

Analogues of the drug Azithromycin

Structural analogues for fluffy speech:

• Azivok;
• Azimycin;
• Azitral;
• Azitrox;
• Azithromycin Forte;
• Azithromycin-OBL;
• Azithromycin-McLeods;
• Azithromycin dihydrate;
• AzitRus;
• AzitRus forte;
• Azicid;
• Viro-Azithromycin;
• Zetamax retard;
• ZI-Factor;
• Zitnob;
• Zitrolide;
• Zitrolide forte;
• Zitrocin;
• Sumazid;
• Sumaclide;
• Sumamed;
• Sumamed forte;
• sumamecin;
• sumamecin forte;
• Sumamox;
• Sumatrolide solutab;
• Tremak-Sanovel;
• Chemomycin;
• Ecomed.

For the presence of analogues of liqivs for fluffy speech, you can go down to the ailments for ailments, for example, a helpful drug, and look at the obvious analogues from the likuvalnoy infusion.

Name:

azithromycin capsules 250mg

INN:

Azithromycin (Azithromycin)
Synonyms:

Azikar, Azilid, Azimed, Azіtroks, AzіtRus, Azіvok, Azіtral, Zіtrolide, Zi-factor, Sumarom, Sumamed @ , Sumametsin, Sumamoks, Sumarom, Chemomycin
Pharmacotherapeutic group

Antibacterial protection. Antibiotics - macrolides.
warehouse

1 capsule contains 250 mg of azithromycin.
ATX code: J01FA10.
Pharmacological activity
Pharmacodynamics

Azithromycin (9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A) may have antibacterial (bacteriostatic) activity. Links with the 50S subunit of ribosomes, inhibiting the peptide translocase at the stage of translation and inhibiting protein biosynthesis, which supports the growth of bacteria, at high concentrations, a bactericidal effect is possible.

Spectrum antimіkrobnoї dії azitromіtsinu wide vіn vklyuchaє grampozitivnі (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalctiae, Streptococcus pneumoniae, Streptococcus pyogenes, streptokok groups C, F, G, Streptococіc,, Bordetella pertussis, Bordetella parapertussis, Campylobacter jejuni, Legionella pneumophila, Neisseria gonorrhoeae , Gardnerella vaginalis) microorganisms, anaerobes (Bacteroides bivius, Peptostreptococcus spp., Peptococcus, Clostridium, ), Mycoplasmas (Mycoplasma pneumoniae), ureaplasmas (Ureaplasma urealyticum), spirochetes (Treponema pallidum).
Pharmacokinetics

Resistant to sour medium, lipophile. Shvidko get wet with ShKT. After a single dose of 500 mg, bioavailability becomes 37%, the maximum concentration in the blood (0.4 mg/l) is reached in 2-3 years. The intake of alcohol and alcohol will change the rate and extent of absorption. At the time of taking the drug, the maximum concentration in the blood (Cmax) is reduced by approximately 50%. It is decided to reach 31.1 l/kg, the connection with proteins is wrapped in proportion to the concentration in the blood and become 7-50%. The period of application T1 / 2 becomes 68 years. A stable plasma level is reached in 5-7 days.

Azithromycin is easy to pass histohematic barriers and to be near the tissue. It is also transported by phagocytes, polymorphonuclear leukocytes and macrophages to the site of infection, deviating in the presence of bacteria. Penetrates through the membranes of clitin (effective for infections caused by internal cellular alarms). Concentration in tissues and cells in 10-50 times higher in animals, lower in plasma, and in the middle of infection - 2-4-34% higher, lower in healthy tissues. High rіven the concentration is taken from tissues for 5-7 days after the last injection. In the liver, azithromycin is demethylated, the metabolites that are metabolized are inactive. Plasma clearance - 630 ml / min. Approximately 50% of the administered dose of azithromycin is excreted from the liver in an unchanged appearance, 6% - from the section. In summer people (65-85 years of age), pharmacokinetic parameters do not change, in summer women - increase in 3 max (by 30-50%). In children of 1-5 years of age, the maximum concentration in the blood was reduced, equal to those of adults, the period of drinking and showing AUC.

Indication before zastosuvannya

• Infections of the upper (bacterial pharyngitis and tonsillitis) and lower (bacterial chronic obstructive pneumonia, interstitial and alveolar pneumonia, bacterial bronchitis) dyhal pathways, ENT organs (angina, otitis media, otitis media);
• Sechostate system (urethritis and/or cervicitis);
• Skins and soft tissues (beshikha, impetigo, sudden infection of dermatosis), chronic stage of migratory erythema (cob stage of Lyme disease);
• Illness of the duct and duodenum, associated with Helicobacter pylori.

Method of stosuvannya that dose

Accept internally

Take 1 time for mining 1 year before departure or 2 years after departure. On the first day, likuvannya is grown up at a dose of 0.5 g per doba, from 2 to 5 days - 0.25 g per doba. Course dose - 1.5 g.

With urogenital infections-1.0 g one time,

For Lyme disease- 1 g of the first day, from 2 to 5 days - 0.5 g each (course dose - 3 g).

In case of ailment of the sluice of the 12-colon intestine, associated with Helicobacter pylori, take 1 g per day for 3 days at the warehouse of combined therapy

For older children 12 months on the first day of therapy - 10 mg/kg body weight 1 time per doba, then for 4 days of therapy - 5 mg/kg/dobu or 10 mg/kg/dobu for 3 days (course dose - 30 mg / kg masi tila).

For Lyme disease- the first day - 20 mg / kg / dobu, from 2 to 5 days - 10 mg / kg / dobu. In the case of missing 1 dose of the drug, the next dose was missed, and the dose was taken earlier, and the onset was interrupted at 24 years of age.
especially vkazіvki

In the case of a frail age, and in ailments with impaired function, there is no need to change dosing.

Pobichna diya

From the side of the shlunkovo-intestinal tract:

Nudity, vomiting, diarrhea, constipation, flatulence, abdominal pain, melena, cholestatic zhovtyanitsa.

From the side of the cardiovascular system:

chest pain, weakness, heartbeat,

From the side of the nervous system:

headache, confusion, drowsiness, sleeplessness,

Other:

conjunctivitis, nephritis, vaginitis, neutropenia or neutrophilia, reverse decrease in the activity of liver enzymes, pseudomembranous colitis, candidiasis, photosensitivity, hanging on the skin, angioedema

Contraindication

• Hypersensitivity (including up to other macrolides);
• Severe damage to liver function;
• Vagіtnіst, lactation (for an hour of likuvannya pripinyat breast vigodovuvannya).

Come in later

With care appoint

• In case of violations, the functions of the nirok are damaged;
• impaired liver function (especially for children);
• With cardiac arrhythmias (possible shunt arrhythmias and lowering of the QT interval).

Given the consideration of the reaction of hypersensitivity in some patients, they can be saved, in which case specific therapy is needed under the supervision of a doctor.
Interaction with other drugs

Antacids reduce the absorption of azithromycin (a break of at least 2 years between doses is recommended).

Irrespective of those that are weak azithromycin, lower erythromycin, that inhibit cytochrome P 450, patients will need a close control in case of one-hour admission of drugs that are metabolized in the liver. Azithromycin potentiates diuretic alkaloids, dihydroergotamine. Upovіlnyuє sekretsіyu, pіdvischuє kontsentratsіyu in plazmі that toksichnіst cycloserine, indirect antikoagulyantіv, metilprednіzolonu, felodipіnu, lіkarskih zasobіv scho pіddayutsya mіkrosomalnomu okisnennyu (karbamazepіn, alkaloїdi rіzhkіv, valproєva acid geksobarbіtonі, deksobardіn, ksebarbіtіn, eksobarbіton, eksobarbіtonі, feprodino, keksodrotin, keksobardіn, kexobardin, exprobardin, phenodipine, valproic acid; medicinal products). Lincosamides weaken the effectiveness, tetracycline and chloramphenicol - improve. Pharmaceutical insane with heparin.

It is not safe to take azithromycin with drugs to keep the QT interval on the ECG.
Overdose

Symptoms:

Timchasova loss of hearing, tedium, vomiting, diarrhea.

Likuvannya:

symptomatic (there is no specific antidote).
Release form

Capsules 250mg in a contour commercial package No. 6.

Virobnik:

For the remaining 35 years of life, thousands of antibiotics of a different spectrum were administered. Ale less deyaki zastosovutsya in medicine, especially in the therapy of children.

Azithromycin is one of these drugs, which is successfully used for the treatment of ailments.

Let's take a look at the instructions for the dosage of the drug Azithromycin 250 mg for children: how to dosing medical care children of a different age, price in pharmacies, fathers.

Description

Azithromycin is a non-synthetic antibiotic, a representative of the azalide subclass, which, according to its structure, is rarely recognized as a macrolide. Tse distribution of the pharmaceutical company Pliva from Croatia.

Infectious speech - azithromycin (250 mg), white crystalline powder. Dodatkovo to the warehouse include lactose, povidone, magnesium stearate, aerosil, microcellulose.

For treatment in pediatrics, Azithromycin is available in two forms:

• capsules;
• tablets in plіvkovіy obolontsi.

The package contains 6 tablets (capsules) in individual boxes.

Indication

Azithromycin is prescribed for infections, such as those sensitive to antibiotics of microorganisms:

Sensitivity to fluffy speech manifests:

• gram-positive bacteria: Staphylococcus aureus, Streptococcus spp;
• Gram-negative bacteria: Borrelia burgdorferi, Bordetella parapertussis, Bordetella pertussis, Campylobacter spp.
• other microorganisms - Mycoplasma pneumoniae, Chlamydia trachomatis, Mycoplasma hominis, Bacteroides fragilis, Treponema pallidum.

Most often, the drug is applied to the liquor of the organs of the upper ventral tract.

About the symptoms and methods of treatment of tuberculosis in children from our advanced state.

Contraindication

Azithromycin in tablets and capsules of 250 mg is not prescribed for children, if it is less than 45 kg, it is easy to choose doses. With a light vase, suspensions are vicorated.

It is contraindicated to recognize the drug in such conditions:

• hypersensitivity - not only up to the first, but also up to other macrolides;
• important forms of rozladіv robotic liver and nirok.

To protect the vicorist, use an antibiotic in case of morbid damage to the hepatic, nirk functions, cardiac arrhythmia and stubbornness to such a pathology.

Vagіtnym tsey zasіb appoint only for extreme necessity. Breast vigodovuvannya for an hour of jubilation is pinned.

Yak dіє drug

Azithromycin lie down to macrolides but it is structurally different from them. Vin may not be a 14-atomic lactone, but a 15-atomic ring, after which it ceases to be lactone.

The symptoms of such a perturbation of the acidity of fluent speech are 300 times greater, lower in Erythromycin, the first antibiotic of macrolides.

Sipping to the drain, azithromycin is not destroyed by hydrochloric acid. In the body, speech does not create a high concentration in the blood, it spreads well and penetrates to rich organs.

It accumulates in tissues, creating great concentrations, and stays there for a trival hour. It has a wide spectrum of activity against pathogenic microbes.

Other advantages of Azithromycin in pairing with Erythromycin:

• more shortly add the shell of gram-negative bacteria clitin;
• better penetrate into adnexal sinuses nose
• active schodo Haemophilus influenzae Pfeiffer (H.influenzae) - the cause of pneumonia, meningitis, epiglottitis (inflamed throat);
• creates high intracellular concentrations;
• dіє bactericidal on pathogens of the middle clitin.

This disease is spread to spirochetes (Lyme disease), rickets (atypical pneumonia), Toxoplasma gondii (toxoplasmosis), gram-negative coli, gram-negative coca.

Azithromycin is excreted from the body once in the feces.

Dosing at different ages

It is recommended to prescribe Azithromycin 250 mg to the instructions for use, children should be dosed regularly due to the susceptibility of the alarm to the antibiotic and the severity of the disease. Standard doses vіd 5 to 10 mg per 1 kg per doba. Trivality to the exchange rate - from 2 to 5 days.

In case of certain illnesses, a correction is necessary, or a dose has been adjusted to a sprat of drugs.

If the dose is missed, then I will start taking the yakomog earlier, and then we will finish the interval at 24 years between the doses of the drugs.

Method of acceptance, special orders

Capsules and tablets are taken internally, do not open and do not withdraw from the capsule, do not remove the shell.

If it is recommended to soak up the liquids, then Azithromycin is taken 1:00 before or after 2:00 after it.

The same may be the interval between drugs and antacids - drugs that reduce the acidity of the stool.

Interaction with other speeches

Azithromycin reacts with such drug words:

• antacids - reduce the blood concentration of speech by 30%;
• indinavir, triazol, midazolam, cimetidine, fluconazole, cotrimoxazole - may reduce the concentration of these drugs;
• digoxin, cyclosporine - it is possible to change the concentration of these agents;
• warfarin - next control prothrombin hour;
• disopiramide - risk of development of mucus fibrillation;
• terfenadine - causes arrhythmia;
• alkaloids rіzhkіv - risk of development of ergotism (true rіzhkіv);
• rifabutin is a risk factor for neutropenia and leukopenia (decreased levels of neutrophils and leukocytes).

Overdose and side effects

In case of overdose, the ailing person suffers from boredom, hearing decreases for a short time. As a result of these symptoms, one immediately seeks medical assistance.