Meldonium mildronate is indicated. Pharmaceutical drug Mildronate; instructions for injection, indicated before injections

Name:

Mildronate (Mildronate)

Pharmacological
diya:

MILDRONAT - drug that improves metabolism. Meldonium is a structural analogue of gamma-butyrobetaine, speech, which is found in the skin cells of the human body.

In the minds of an advanced ambition Mildronate® is responsible for the equal delivery and demand of clitins in the intestines, the accumulation of toxic products in the clitins, protecting them from diseases; may also be a tonic infusion. As a result of this stagnation, the organism is gaining viability and victoriousness, and quickly replenishing energy reserves. Mildronat® vicarious for the sake of various disorders of the heart-vascular system, bleeding of the brain, as well as the promotion of physical and rozumova praceszdatnost.

As a result, a decrease in the concentration of carnitine increased the synthesis of gamma-butyrobetaine, which leads to vasodilatory power. With acute ischemic myocardial damage, Mildronate improves the elimination of the necrotic zone, a short rehabilitation period.

With heart failure the drug increases the speed of the myocardium, increases the tolerance to physical ambition, reducing the frequency of angina attacks

With gostrih and chronic ischemic disorders cerebral blood flow to improve blood circulation in the ischemic cavity, spray redistribution of blood on the crust of the ischemic plant.

Efficient in case of vascular and dystrophic pathology of the ocular fundus.

The drug restores functional impairment of the nervous system in patients with chronic alcoholism with withdrawal syndrome.

Displayed up to
zastosuvannya:

Mildronat vicorist at the warehouse of complex therapy:
- Chronic heart failure,
- IXC (myocardial infarction, angina pectoris),
- dyshormonal cardiomyopathy,
- chronic and hospitable cerebral circulatory disorders,
- as well as withdrawal symptoms in patients with alcoholism;

Other indications:
- reduced pratsezdatnіst,
- postoperative period for changing the term of rehabilitation,
- physical overvoltage,
- hemophthalmus,
- thrombosis of the central vein of the network,
- bleeding into the system of various etiology, hypertensive and diabetic retinopathy (for parabulbar insertion),
- chronic bronchitis and bronchial asthma (as an immunomodulator).

Way to zastosuvannya:

At zv'yazku z zhlivіstyu development zbudzhuyuchy efektu drug it is recommended to stop at the first half of the day.

With cardiovascular disease at the warehouse of complex therapy, the drug is prescribed at a dose of 0.5-1 g per doba. intravenously (5-10 ml each for injections with a concentration of 500 mg / 5 ml), the frequency of ingestion is 1-2 times per doba. Likuvannya course - 4-6 days.

With impaired cerebral circulation in the acute phase, the drug is administered intravenously at a dose of 500 mg 1 time per doba. protyag 10 days, then switch to taking the drug internally (in the main dosage form - 0.5-1 g per doba). Hot therapy course - 4-6 days.

With vascular pathology and dystrophic diseases of the system Mildronate is administered parabulbarno at 0.5 ml intervals for injections at a concentration of 500 mg/5 ml for 10 days.

Assign intravenously at 500 mg 1 time per doba. Likuvannya course - 10-14 days. If necessary, repeat therapy after 2-3 days.

With chronic alcoholism the drug is administered intravenously at a dose of 500 mg 2 times per doba. Likuvannya course - 7-10 days.

Pobichna diya:

Ridko - allergic reactions(chervoninnya, hanging, sverbіzh, nabryak), and bring on dyspeptic manifestations, tachycardia, change in AT, awakening.

Contraindication:

Mildronate contraindications for manifestation of hypersensitivity to the drug, with vagity and lactation, with intracranial hypertension, including with intracranial tufts, impaired venous flow.

Interaction with
other medical-
by them:

Mildronate enhance the effect of cardiac glycosides, coronary dilating agents and effective antihypertensive drugs Sumy s antiarrhythmic, antianginal drugs, antiplatelet agents, anticoagulants, bronchodilators and diuretics.
Slid buti we will protect when we go with nifedipine, nitroglycerin, alpha-blockers (possible development of arterial hypotension and mild tachycardia).

Vagity:

Safe congestion of Mildronate with vaginess was not brought. In order to get rid of the possible unacceptable influx on the fetus, the drug did not show signs of pregnancy.

Mildronate is a medical drug that improves metabolism in the body of a person and promotes the safety of organs with brown speech. Faces spryaє napovnennuyu clitin energy when other illnesses, for example asthma, retinopathy and heart disorders.

Form release

Mildronat is released from the eye:

• Retailers for injections. Ampoules to take 5 ml of speech; in the package - 2 cores of 5 pieces.
• Capsules, in some retail powder; in the package - 4 plates of 10 pieces. It is fenced to open the capsules, to open the faces before the implantation.

warehouse

Gelatin capsules are available in two types - 250 and 500 mg. At the warehouse - meldonium, speech, sho dіє, as well as sprats of additional speeches. The capsules themselves are prepared with gelatin and titanium dioxide.

Ampoules of injectable variety contain 10% concentration of meldonium phosphate and a small number of additional speeches, mainly physical. rozchin.

Pharmacological activity

The main component of the drug is meldonium, a synthesized drug that is like γ-butyrobetaine, which is a distant relative of category B vitamins.

Rice is characterized by meldonium - richness in metabolism, so that the exchange of speech, that supply of various cells to the body with energy. Zastosovuєtsya as zasіb zahistu hearts and wild organs. The type of speech allows you to reduce the tension of the body.

Meldonium changes the frequency of attacks of angina pectoris and increases resistance to physical stress on the body, increasing the pressure on the heart. Normalization of blood circulation, directing blood to support the point of ischemic injury. Upovіlnyuє utvіlnya utvіlnya nekrotіchnyh skupchenі and zmenshuє zagalnu trіvalіst vіdnovlennya organіzmu.

Faces sprya rozchinennyu a bunch of speeches, priyayuchi delivering brown ones for confessions and seeing shkidlivih. Tsya power helps to renew every hour and then after the end of physical adventures, boosting the speed of metabolism on the flat water.

Meldonium promotes the work of the central nervous system, suvayuchi disruption in various scenarios. Also, spryyaє likuvannu dystrophy sitkіvki eye.

Pharmacodynamics and pharmacokinetics

Meldonium allows you to reduce the amount of unoccupied carnitine, speech, which creates transitions for the transport of speech by clitins. Lowering the concentration can also lead to an increase in the vibrated γ-butyrobetaine. In the middle of ischemic disorders, it stimulates the mutual interaction of delivery methods and the treatment of sour stools, as well as the rapid need for sour stools, activating glycolysis.

The maximum concentration of active speech in the blood is present after 60-120 minutes after intake to the body. Faces are laid out in a non-stop speech. Nirks spy on the vision of speeches that have hid in the process of decay. Trivality napіvrozpadu to become vіd 180 to 360 hvilin, fallow vіd organism and dose of the drug. Qi hardening is useful for capsules.

In'єktsії, navpaki, mayut ovnu biological accessibility, to that child the speech begins immediately after the introduction. The introduction of products in the decay is similar to the hour and also becomes 180 to 360 minutes from the moment of introduction.

Indication

Faces of creation are recognized for the jubilation of the osib vіkom vіd 16 rokіv. There is a small number of data about the impact on the child's body to report about the fence against the medication for the good of children.

Overhead display before zastosuvannya:

• Ischemic disease of the heart (like a dodatkovy drug).
• Peripheral rupture of the arteries.
• Dyscirculatory encephalopathy.
• Variation of various directives: physical, intellectual, mental.
• Post-operational camp (as zasib, which will speed up rehabilitation).
• Chronic angina pectoris, cardialgia, asthma, obstructive ailment legeni.
• Alcohol withdrawal.
• Stroke.

Additional indications for vicarious injections:

• Hemorrhages in the eye area.
• Venous thrombosis in Sitkivtsi.
• Retinopathy.

Sport

Mildronate helps to change the body's susceptibility to physical urges, which allows you to beat the odds for an hour of static exercise. The effectiveness of the training is significantly improved, the shards of meldonium spice the vitality of the body with brown speech and change the scorching rive in the volume. Faces do not spriyaє naroschuvannu m'yazovoї masi, but є є zabom profilaktiki reevtomi organism.

Speech is active quickly after decay, with the help of cellular metabolism and renewal of energy. The values ​​of particularity are positively injected into the various physical vanities, the shards are used to bring inspiration to minds.

Mildronate is used to protect the liver from fatty acids, to spit out tsukrіv, so that it increases the intensity of speech, which synthesizes energy at the exit.

In combination with cym, the drug is administered by doping. Yogo zastosuvannya in sports is fenced.

Contraindication

General contraindications before taking Mildronate:

• Increased sensitivity to components.
• Intracranial hypertension.

Side effects

By taking mildronate, we call out the side effects:

• Allergic, which is manifested in the look of black or visipan, as well as vermin.
• Dyspepsia, which manifests itself as boredom, baking, vomiting.
• Zbіlshennya rіvnya zbudzhennya organism.
• Tachycardia.
• Decreased level of AT.

Installation instructions

Mildronate is sold in ampoules for injection, but the patient often asks: “What is internal?” Instructions to talk about administering medication for intravenous administration. Faces are carried out at ready-made forms. The introduction should be carried out only with other preparations, but in some cases it is allowed to introduce a physical dose at once.

Instructions for injecting 5 ml injections of mildronate.

For patients who suffer from corticosteroids, the drug is administered intravenously, in a strumming way. Dosage - 1-2 ampoules, fallow for symptoms, not more often than once every 24 years. The course of treatment is accompanied by capsules, which are taken after completion of the course of injections.

For patients with ailments of the vessels of the eyes, the drug is prescribed for 10 days. Pricks are carried out under the ovnishnyu shell or for very apple. One 5 ml injection is usually vibrated.

In case of problems with blood flow, a ten-day course is prescribed. Mildronate is administered intravenously, 1 ampoule a day. Similar to patients with corticosteroids, follow the treatment with capsules. In case of chronic problems due to blood circulation, it is recommended to colitis mildronate internally. Dosage - 1-3 ampoules per day for 15-20 days.

Zastosuvannya capsules

In case of damage to the work of the cardiovascular system, 500 to 1000 mg of speech is prescribed for 30-45 days. Dose the drug to be recommended to patients.

In case of cardialgia, caused by dyshormonal myocardial disease, drugs are prescribed in a quantity of 250-500 mg to the skin. In case of impaired blood flow, it is indicated to take 1-2 large capsules per day. If the disease is chronic, then 1 large capsule per day. For cih zahvoryuvan course to become vіd 30 to 45 days. The doctor installs the term and the frequency of the course of fallow due to severity. The course can be conducted no more than three times per river.

For arterial pathologies, take two large capsules a day, one in the morning, one in the evening. It is analogous to overwhelming the body. Trivality to become from the second to two tyzhniv. The course can be repeated, but only after 20 days from the end of the previous one.

Athletes can take speech in the amount of 500 to 1000 mg per day. The course is three 15-20 days before the start and 10-15 days before the start.

Patients with chronic alcoholism are shown to take the drug 3-4 times a day in capsules of 500 mg each day.

The capsules can be diluted, but not recommended.

2000 mg is the maximum allowable amount of the drug, as it is taken as a single dose.

Overdose

The fact of overdosing with mildronate has not been recorded at the moment. The medicinal preparation is considered non-toxic and does not cause side effects that are not safe for life.

Interaction with others

Combining mildronate with other drugs is acceptable. Before the list of speeches, which can be combined, one can see:

• Protian, protiarrhythmic, proticoagulant, antiaggregant
• Diuretic drugs.
• Heart glycosides, bronchodilators.

People also help the robot with nitroglycerin, antihypertensive speeches and succumbing to the judge, as well as nifedepin and similar to new medications, with coronary heart disease.

Brief information about mildronate

Faces are allowed in pharmacies only for the recognition of a doctor.

It is necessary to save speech in a dry, inaccessible place for children. The temperature of the application, bagan, may become a little more than 25 degrees Celsius. The term of appurtenance - 4 years.

additional information

Mildronate is a stimulant, due to which it is allowed to stop until the 12th day of the day.

The drug, for the sake of familiarity, does not interfere with the rapidity of the reaction, but rather the health of the transport.

The prescription of the drug by patients with pathologies of organs, which is to be taken - livers and nirok - is not blocked, but the recommendation of a specialist is necessary.

Mildronate is not considered a first-line treatment for patients with acute coronary symptoms. Data were withdrawn as a result of treatment of patients with angina pectoris or myocardial infarction.

Implantation of mildronate in combination with alcoholic speeches

Meldonium, which is the active part of the drug, is excreted from the body in the average for 10-12 years. By the end of the term, the risk of combining antibiotics with active speech is insignificant. At the end of the life of alcoholism, the drinks are not defensible;

Implantation of alcohol-based speeches with a liquor with mildronate can be called:

• Allergic reaction to the body, expressed by hanging and/or severbine.
• Rizke decrease in arterial pressure, tachycardia.
• Dyspepsia - nudity, vomiting, baking and similar symptoms.
• Mozhliviy rizik makes it easy for a recurrence of an ailment.

Mildronate for pregnancy and lactation prolongation

It is not possible to say with certainty that mildronate can be congested with vagity. To exclude the risk of pathology in children, the drug is not prescribed as a protractor of pregnancy. Similarly, the lateness of the ingestion of fluffy speech into the milk at the beginning of the year was not brought, after which the introduction of the drug with lactation was taken.

Varity of the drug

The average variety of smaller capsules, 250 mg, is 260 rubles per package. The price of 500 mg is about 600 rubles. The price of 10 ampoules is, on average, 350 rubles.

Mildronate є kindly likuvannya zahvoryuvan heart, and also spryyaє following the great adventures. “Which can you mix yoga with?” - food for the doctor, but it’s clear that it’s not varto to work. Zokrema, don't make faces with alcohol.

Also, wines are used for treating certain ophthalmological pathologies, increasing vibrancy both physical and intellectual.

Є kіlka forms of release of Mildronat, skin z of which may be recognized, depending on the severity of symptoms, I will become ill or yogo special troubles. Call the doctors to prescribe injections of Mildronate in depression, if it is necessary to achieve a therapeutic effect, or if you have ailments, you cannot take pills. Depending on the course of administration, you can continue, switching from injectable to the oral form of the drug.

Description of fluffy speech

Zgidno z іnstruktsiєyu іz zastosuvannya Mildronatu in yogo warehousing with fluffy speech є meldonіy or trimethylhydrazinіya propionat digidrat. Behind the structure, it is an analogue of gamma-butyrobetaine, which is present in all human cells. The mechanism of action of meldonium affects the blocking of carnitine conversion, after which the synthesis of gamma-butyrobetaine is promoted. Vіn priyає expansion of the vessels and more effective blood supply of tissues, especially quiet, which is known in the minds of hypoxia.

The drug protects cells from an aggressive infusion of catabolism and toxin products, speeding up the removal of these agents from the body. In case of ischemia of the tissues of the organs (for example, myocardium, brain, tissues of the organ of the brain), meldonium changes the spontaneity of the blood flow to the measles of the areas of hypoxia. In this way, yoga anti-chemic and anti-hypoxic disease manifests itself.

In the minds of acute myocardial circulatory failure, Mildronate is used to improve the formation of necrotic ushkodzhenya and a short rehabilitation period. With angina pectoris, the drug changes the number of attacks of anginal pain, improves heart failure. Zavdyaki youmu, stimulation of neurons is moving, activation of the rukhovo sphere and physical vibrancy is observed. Also vin may protistress diyu.

Meldonium shortens the recovery period in patients who suffered from vessels, inflammation of the brain or CNS injuries. Vіn zmenshuє disruption ruhіv (paresis), priyaє improved coordination, reducing the vegetative manifestations. With the help of the drug, I will reduce the number of patients with alcohol addiction, change the manifestation of the withdrawal syndrome.

Pharmacokinetics

The maximum plasma concentration of Mildronate for injection may be reached immediately after parenteral administration. Vіn shvidko rozpodіlyaєtsya in tissues and zv'yazuєtsya with proteins of blood plasma. Bioavailability of the drug to become 100%.

Respect! The drug often penetrates through the hematoplacental barrier, and it is also shown to be consumed in breast milk.

Metabolism of Mildronate occurs in the liver

The preparation of this yoga metabolite is most importantly administered with nirkami. The period of drinking is 3-6 years old.

Indication

Why stop Mildronate, and if we can make wine? Indications for drug administration are also pathological:

• cardiovascular pathology: chronic ischemic heart disease; angina; myocardial infarction; chronic heart failure;
• dyshormonal cardiomyopathy;
• vegetative-sudinal dystonia;
• chronically impaired blood circulation in the brain;
• brain stroke;
• pathology of peripheral arterial vessels;
• initial postoperative period;
• bronchial asthma and chronic obstructive disease of the leg as a component of complex treatment;
• ailment of the eyes of different genesis: bleeding in the eyes and sloping eyelids, retinopathy (hypertensive and diabetic), thrombosis of the central vein of the eyes, impaired blood supply to the eyes.
• chronic alcoholism and withdrawal syndrome in alcoholic patients with other types of alcoholism;
• high physical stiffness and overvoltage;
• low productivity of physical and intellectual work.

Respect! In case of ailments, the organ is shown to take injections of the drug Mildronate only parabulbar.

In case of cardiovascular pathology, injections of "Mildronate" and warehouse complex therapy for ailments cannot replace the constant treatment with basic drugs.

In the middle of the show, before the stagnation of Mildronate, their niche was known and sports training with the method of promoting vibrancy, swedish renewal after important and trivaly to take up sports.

How to take the drug?

Rozchin Mildronate may have a concentration of 10% meldonium. Available in ampoules of 5 ml. Apparently, in 1 ml of retail - 100 mg of meldonium, and one ampoule - 500 mg. The box has 10 ampoules. The drug is prescribed 1 or 2 times a day. Rozchin the drug can be administered in a kіlkom way:

• internal language;
• internally;
• parabulbarno (bіlya full-time apple).

Mildronate should be administered internally in the strumine way, so you can more easily reach the bagan effect. If you do not take the drug as a hospital, then you can inject yoga into a vein by infusion for additional urticaria.

The drug at a glance can not be diluted before administration

Rozchin Mildronate is produced at a sufficient concentration of fluent speech and does not require additional dilution. The cost of all methods of injection delivery of the drug. Proteolists can recognize yoga, for example, on a physical basis. If Mildronate is still bred, then the absolute quantity of fluent speech does not change, it changes only one concentration, which can be recognized by the current strength of the drug.

In quiet moods, if the swede is not needed, you can breed Mildronate. Tilki z tsієyu method is better to vicorate 0.9% of sodium chloride (fizrozchin). Contact with other retailers can be recognized for the power of the drug, which is extremely unbearable.

Mildronate activates nerve action, so take yoga at least 4-6 years before bedtime. Otherwise, sleep can be disturbed like sleeplessness. The additional dose can be taken in one injection or divided into two doses.

Dosing for various pathologies

The dose of the drug should be taken depending on the specific disease and is selected by the doctor individually:

• Unstable angina pectoris and myocardial infarction. In such cases, an intravenous administration of the drug is indicated, scallops become acute and sway the negaic insertion. Administer 5-10 ml of Mildronate strumine intravenously. In case of poor tolerance to injections, the entire dose should be administered once; The validity of parenteral drug administration should be established within 1 to 10 days. Nadal, you can switch to the oral form of Mildronate and take yoga with a general course of trials up to 4-6 days.
• Chronic insufficiency of blood circulation. Take 5-10 ml intravenously 1 time per day, or 5 ml of the drug for internal doba. The course is three to 2 days from the transition to syrup or tablets.
• Ophthalmological pathology In this case, Mildronate is congested parabulbarly, 0.5 ml per doba (50 mg meldonium) for 10 days.
• Stroke of the brain in the acute phase. In order to achieve a firm effect, the drug should be administered intravenously, 5 ml per doba for 10 days. You can also inject yoga intravenously at 500 mg 1 time per doba for 2-3 days.
• Chronic insufficiency of cerebral circulation. In case of this pathology, the drug should be administered either internally or in tablet form. Inject 5 ml intravenously 1 time for 14 days. The reception is carried out for the demand up to 4 days.
• Dishormonal cardiomyopathy. Take 5-10 ml intravenously strumine per injection per doba or 5 ml intravenously 2 times a day. The course should be 14 days, and if oral administration is continued, it is recommended to take Mildronate for 2 more days.
• Chronic alcoholism. Ailments take Mildronate intravenously strumine 5 ml 2 times per doba for the treatment of neurological symptoms. Continue therapy up to one day.
• Increased stubbornness in periods of high physical and intellectual advancement. Acute need for parenteral administration of Mildronate with such indications is not possible, it is better to keep everything in order, which method is more acceptable for the patient, and if there is a slight effect on the wines. The drug is taken internally, 1 ampoule 1 or 2 times a day. Possible and internal administration of Mildronate in a similar dosing regimen. The course of likuvannya to become up to 2 tizhniv. If necessary, yoga can be repeated after 2-3 days.

As with chronic damage to cerebral hemorrhage, damage to the forging or problems from etching, follow the parenteral route for the introduction of Mildronate

Interaction

Mildronate, in conjunction with other medical procedures, can cause a lot of bugs, and unsafe reactions to the body. Too many patients to cry, so you can take meldonium with other drugs. Definitely, you can give more than a doctor for the same supply.

Meldonium promoting efficiency:

• antiplatelet agents;
• anticoagulants;
• bronchodilator diseases;
• antiarrhythmics;
• antianginal drugs;
• diuretics.

When Mildronate is recognized, always warn the doctor about taking any medications and about concomitant illness

The drug is potent for beta-blockers and cardiac glycosides. With special care should be taken when taking Mildronate with such drugs:

• alpha blockers;
• nitrates;
• antagonists of calcium channels;
• peripheral vasodilators.

Spilny priyom tsikh zabiv can lead to a sharp decrease in arterial pressure and tachycardia.

Contraindication

Vіdpovіdno to іnstruktsії іz zastosuvannya drug, yoga is not prescribed in such cases:

• vaginess;
• lactation period;
• child age up to 12 years;
• allergy or manifestation of individual hypersensitivity to meldonium.

Side effects and drug overdose

There is a high degree of tolerance to the drug among patients, but sometimes there are fluctuations. side reactions on Mildronate:

• shkіrnі alergіchnі show at vyglyadі visipu, kropiv'yanki, rіdko - angioneurotic blotch Quincke;
• dyspepsia;
• kolivannya krov'yannogo vice;
• frequent heartbeat;
• sleeplessness and psychomotor arousal;
• weakness;
• changes in blood formulas (advancement of eosinophils).

especially vkazіvki

In sick people who may be seriously ill with a liver disease due to a lack of functions of these organs, follow the control of biochemical signs of blood. If you need to take meldonium obov'yazkovoy є consultation of a doctor for dose correction for the patient.

Lyudina, as she takes Mildronate, can be allowed to be cured by transport means and by means of mechanisms, but the drug does not cause an increase in reactions. Patients of the frail age should change the therapeutically effective additional dose.

Zastosuvannya in sports

Zavdyaki zdatnosti Mildronata increase sourness in tissues, it can be recommended to increase tolerance to physical vanity. Vіn improve the eating of the myocardium and peripheral mucus. Tse priyaє iznizhennu vtomi that svidkou vіdnovlennyu after training.

Until recently, meldonium was not affected by doping, and since 2016, yoga was included in the list of drugs, as sports are considered doping.

Wash away the savings

If the ampoules are broken, they don’t take care of savings for everyday furnishing. Refrigerator іz tsієyu method tezh not fit. After 20 minutes and more, after the seal is broken, the ampoule should be discarded.

Notes about Mildronat

Patient feedback about the drug is more importantly positive. The thoughts of doctors about Mildronata are different.

On the other hand, there are Mildronate therapy patients, which indicate the high effectiveness of the medication in their ailments.

The evidence base for the drug Mildronate may be daily, and it is comparable to the placebo effect.

Mildronate took promotion of practice during the period of studies at the institute. I can only say well: the drug does help to improve the memory of the material. I could not sleep for a long time, knowingly to myself well badioro. Vіn for єyu єyu nagaduє energetik less without side effects.

Valentine, 58 years

The drug made me happy to take Mildronate after more frequent attacks of angina pectoris. I took intravenous injections every day, then 3 more drank syrup. During this period, the attacks of pain stumbled, maybe there are no asses.

Irina, 42 years old, medical cardiologist

Mildronate improves the tolerance of physical changes in patients with IHS. Vіn good vplyvaє on self-feeling sickness on vegetative-sudinal dystonia. During therapy with the drug, the symptoms regress more and more, and if a course is necessary, repeat every hour.

What is the need to breed Mildronate for internal administration?

One doctor seems to be possible, the other one can make the ampoules grow. Which one looks like Million will be effective either pure or bred on a physical basis or glucose?

The drug Mildronate is already available at 10% in ampoules of 5 ml, administered intravenously without dilution at the dose prescribed by the doctor, so you will dilute the drug physical. rozchino, then there will be nothing terrible, even if the drug is overdosed with too much, just wait until the introduction process, and the effect will be three times worse, with glucose or other drugs, it is not recommended to use it.

Can you administer mildronate internally?

Mildronate can be called a universal fighter of its kind: the drug is prescribed for various illnesses. The speech of yogo, meldonium is active, speeding up the intercellular exchange of speeches, helping the body to get rid of a lot of ailments and become apparent after a serious adventure.

Instructions from the application: the drug can be taken orally - in the form of capsules, or you can, if you do not give injections, stab internally - or ask for yoga from pharmacists in ampoules. Also, can you administer mildronate internally?

Mildronat: one hit per thousand bd

The scope of these antibiotics is really wide.

Instructions from the application of mildronate to say what wine is necessary for:

• the most visible inspiration after the great physical and rozum visions;
• we are sour;
• creating a barrier for toxins that accumulate in cells;
• tone of the whole organism;
• increase in the frequency of the myocardium;
• reduced blood circulation;
• usunennya damage to the nervous system, especially for dwindling alcoholism;
• muscle contraction.

The very same diagnosis, for which doctors prescribe mildronat, is rather rich:

• chronic heart failure;
• gostra ischemia;
• angina; myocardial infarction;
• broken blood circulation.

Also, yoga is often proclaimed with a decrease in practicality, swedish stubbornness, post-rozumovyh and physical whims.

It is noteworthy that the speech of the drug, meldonium, can have the same structure, that the speech of the collapsible name of gamma-butyrobet and can be manifested in the skin cells of our body. In case of yoga failure, it is recommended to administer mildronate. Zgidno s іnstruktsiєyu іz zastosuvannya, similar power volodіє і whether it's an analogue of mildronat, such, before speech, chimalo in pharmacies: melfor, vazomag, medatern, idrinol.

New mildronate for bodybuilders?

What is metabolism?

Powerful faces, like playing into the hands of athletes, rightly so. Mildronate:

• ensure the delivery of the acid to all customers;
• pereskodzhaє accumulation in clitins of the most fatty acids;
• helps to live the m'yazi more quickly;
• knowing the pressure, accumulated in that, promoting practice;
• serve as a guarantee for the effectiveness of training;
• protect the heart against the advancing ambition.

It’s the same that the drug can be used in a richly stylish term to invigorate an organism, to make it stronger, and therefore, to take richly good results.

Dosing of the drug

Vypuskayut mildronat in capsules or in ampoules. Glitaty or administer - a special choice of the skin, but all the same, zgіdno z deakimi doslіdzhennym, as the drug is injected internally, the effectiveness of yogo growth is approximately double. To the very same, the instruction from the zastosuvannya to introduce a little month for the introduction of the dosing of the likivs: it is not only for other illnesses, but also for the zastosuvannya of the various forms of release.

For example, athletes take 0.5-1 g of internal alcohol per day. The course for the receptionist should be 3 days a week before the start of preparation for 10-14 days during the active period of sports competitions and reach.

With rozumovyh and physical urges, you can enter 250 mg of lika as many as 4 times per doba! Stab the vein so often, more so that the course of the lure is three for 12 days, wait a minute, try more. To that yogo it is better to take capsules.

And the axis in the case of heart-sudine ailments needs to be administered intravenously with mildronate - 1 gram of active speech two per day. Come stock up on patience: the course of likuvannya is three 4-6 days.

Can you administer the drug internally? Instructions from zastosuvannya, folded with a virobnik, this method is not passed on. The same doctors with fights are put to the point of idea. First, the effectiveness of the drug is now decreasing. In addition, a lot of drugs are guarded: the introduction of internal language can cause an allergy, and such an injection itself can be called more painful. To that, in view of the idea of ​​​​working the internal language injection, it is more likely to be encouraged: the fire is not a candle.

Contraindications and side effects

Not caring about your own privileged authority, it is necessary to work with mildronate with great care: wine is for the tim, who calls out side effects. Among them - m'yazove zbudzhennya, quickened heartbeat, sverbіzh, visip and chervonіnnya on shkіrі, nabryak at the mist of the injection. Even if you want to reveal one of the side effects for yourself, it’s a serious need to take the drug and turn to the doctor.

Moreover, chimalo had that contraindication.

• promotion intracranial vice;
• chronic ailments of the nirok and liver;
• Vіk till 18 roіv;
• period of pregnancy and breastfeeding.

Let's make a row of virobniki guard against the reception of liquor during the period of drinking alcohol. Remember: mildronate and alcohol are absolutely crazy!

Mildronate - rozchin for injections

Mildronate is considered to be a medical drug of synthetic origin. Instructions from zastosuvannya indicative of those who need regular and correct methods to improve energy efficiency and exchange of speech and use of fabrics. The dominant warehouse component is meldonium. Most often, it is punished to patients with a diagnosis of ischemic heart disease, dyshormonal cardiomyopathy, heart failure and stroke.

warehouse

Lіkarskiy zasіb u formі razchinu іn'єktsіy vypuskaєtsya vyglyadі prozorої rіdini, scho not maє vіdtinku. The leather cardboard box contains 10 ampoules with a volume of 5 ml, packed in blister packs.

The main active ingredient is propionate dihydrate. For skin ampoules, increase to 100 mg. In the middle of the dodatkovyh storage cavities, there is less sterile injectable water.

Cream administered to the drug internally, Mildronate is also viable in tableting and capsular form. The drug in capsules is carried out at a concentration of 250 and 500 mg of the active ingredient. The body of the capsule of vicons is made of special gelatin, which is quickly spread under the infusion of shell juice.

The additives in the capsule form of the drug are: calcium stearate, viconium capsule body with gelatin and titanium dioxide. Pack capsules in blisters of 10 units, also seal in a branded box (4 blisters for skin),

Tablets are vibrated in a single dose, so as to become 500 mg of the active ingredient. Among the additional speeches here are: mannit, povidone, potato starch, silicon dioxide, cellulose microcrystals, magnesium stearate.

Indication

The pharmacists of the medical profession see the following series of indications, when they prescribe Mildronate internally or orally:

1. Heart failure;
2. Dishormonal cardiomyopathy;
3. ischemic heart disease;
4. angina pectoris;
5. myocardial infarction;
6. stroke;
7. Cerebrovascular insufficiency.

It is no less effective to take drugs in case of frequent and severe physical overstrain, as well as a decrease in the rate of administration, thrombosis of the vein of the eye network or hemorrhage of various genesis, with hemophthalmitis, withdrawal symptoms, retinopathy. different forms, including diabetic and hypertensive.

Contraindication

Instructions for administering injections of Mildronate indicate an offensive number of contraindications, for the obviousness of such victories, it is unacceptable in therapy:

1. Increased individual sensitivity to the main component of the licks or additional warehouse speeches;
2. Imovirnist vyniknennya allergic chi side reactions in the process of treatment;
3. High intracranial vice;
4. Dysfunction of the venous blood flow;
5. Puhlini, which are localized in the middle of the skull;
6. The age of the patient is less than 18 years;
7. Be-yaky trimester vinoshuvannya ditini;
8. The period of breastfeeding.

It is especially important to recognize that Mildronate should be taken by people who have dysfunction or pathology of the liver.

Way to zastosuvannya

The medicinal difference for injectable doctors is to introduce trioma in different ways: internally, internally, or through the skin into the bottom pit. Otzhe, pіd vіdnіshnyovennym vіdnіvnyam mаyut іn іnієktіyny іn'єktіynyy urskuvannya vein vіn, vіn vіn vіdnuєsya sіrovatkoy krovі.

If the drug is administered intravenously, then a bunch of veins should be located at the m'yazovі fibers, and then the stars will progressively spread along the tissues and penetrate the blood. Most of the patients lie at the entrance of the blind eye. Ale not varto hvilyuvatisya, as if in'yektsiyu rob dosvіdcheny fahivets. Such a method of injection is absolutely necessary to fight against eye diseases.

There are many different types of injections for Mildronate for different types of injections. All vikoristovuєtsya of the same rozchin, which representations in a concentration of 100 milligrams per 1 milliliter of rindine. Categorically zaboronyaєtsya vykonuvati roztin ampoules behind the back. Tsya procedure can be vikonuvatisya before the injection. Rozchin not appointments for sberіgannya on vіdkritu poіtrі or in the minds of low temperature, like opening an ampoule, Mildronat is placed in a syringe.

The maximum hour after the growth of the ampoule should be less than 20 quills. If the introduction of the hourly period ends, it will be necessary to leave the liquor, and the injection should be taken out of the newly opened ampoule.

So before tim, how to dial up the syringe, it is necessary to take a resolute look at it. The faces are not guilty of changing the color, yogo traced to the presence of plastics and other houses. In case of manifestation of non-typical components, Mildronate vicory is boronated.

Instructions are given to those who carry out the procedures of injections of varto vranci or before the offense, which is mindful of the stimulating effect of Mildronate. In quiet situations, if the patient is prescribed more than one injection for the doba, the rest of the introduction of the next work is not later than five years before going to sleep at night. Even if you don’t have a fight, and ailments, you can take an injection yourself, you can carry out the procedure at home. In this case, it is important to follow all antiseptic rules in order to allow the penetration of infection into the area of ​​infection.

In case of recognition of intra-shnyovenny and parabulbar introduction, the procedure should be considered less for the minds of the polyclinic. Vignette injections for internal injections can be called medical practitioner on dim.

Dosing

Standard doses, the interval between intravenous and intravenous injections of the doctor's prescription, vary however. Depending on the extent to which a therapeutic effect can be obtained, the method of injection is chosen.

In such situations, if the patient is in a critical state, then for the short-term adoption of inadmissible symptoms and the advancement of the progression of the pathological state, it is necessary to choose an internal introduction, which is swayed by the rapid penetration of the infective component into the blood, effectively, effectively.

If necessary, the reach of prolonged speech, so that the speech was divided and entered the bloodstream properly, to give priority to internal language injections. This technique is best suited for the treatment of pathologies that occur in chronic forms.

Zvіdsi you can make a short visnovka, which is internally introduced to the truth for the acute state of sickness, and internally - in chronic pathologies. The introduction of the parabulbar method is shown to be vinyatkovo for the therapy of ophthalmic diseases.

Considering the standard dose, as indicated in the instructions for the zastosuvannya likarskogo zasobu, Mildronat is prescribed a volume, which is 500 milliliters with a stretch, which is good for five ampoules. Tse zastosovuєtsya to vnutrishnyovennyh or vnutrishnyom'yazovyh іnєktsіy.

For injection into the eye area on the doba, no more than 50 milligrams of the drug is indicated, which means 0.5 milliliters. Also varto designate that the dosing can be changed for the greater or lesser side by the doctor. Tse mozhe nadobitisya with hospitality, or, on the other hand, not very pronounced pathological camps, then, lie down without a middle in the case of severity of that development, as well as in the form of illness.

Myocardial infarction and unstable angina pectoris. The introduction of Mildronate is carried out in an internal way. The additional dose should be set from 500 to 1000 ml. Significance of volume in the patient's body can be found in one or two procedures.

Apparently, it is important for a patient to tolerate injections, so it is better to administer the entire dose in one procedure. In quiet situations, if a person is normally taken to internal injections, it is more likely to administer two doses for doba, dividing the dose into equal parts, then per milligram.

It is even more important that the entire prescribed dose of the drug was injected into the body with a single dose. Away, you can spend the lure of taking oral forms of Mildronate.

Але при цьому, якщо пацієнт, з індивідуальних або інших причин, наприклад, у нього спостерігається дисфункція, патології ШКТ, не може набувати таблетованої форми засобу, а також при низькій ефективності терапевтичної ефективності після їх прийому, то надалі лікування проводиться шляхом виконання внутрішньом'язових injection.

For such a scheme of therapy, patients are shown procedures for a period of one to two months. Dosage should be set at 500 to 1000 mg of Mildronate, and the interval between injections is up to 3 additions. Indications of volume can be administered twice, dividing the dose into 2 injections or once.

Heart failure of a chronic type. The back is beaten internally by the introduction of a medical care in a dose of 500 to 1000 milligrams with a stretch, which is more expensive 5 or 10 milliliters, depending on the case. It is allowed to add more internally to the introduction of Mildronate. With this, the dose in one injection can become 500 mg of the drug. The duration of therapy is from 10 days to two days.

After that, as the main course of treatment by the medical method of intravenous or intravenous administration was completed, the patient should be taken to oral administration of the drug Mildronate. The validity of such therapy will become close to a month, and not less than 21 days.

If the patient is ready for a medical mortgage during the period of severe damage to the blood circulation in the brain, then it is indicated for him to add an internal injection of 500 milligrams of the drug for a duration of 10 days. Upon completion of the course of intensive therapy, the patient may be asked to switch to oral forms of Mildronate, or to continue with injectable procedures, or even internally.

With the help of the path of introducing liquids into the m'yazovі fiber, it is recommended to carry out the procedure once for extraction, at the same time, 500 milligrams of the medicinal product is administered to the sick person. Trivality of jubilation to become two to three types. If a patient has been diagnosed with a chronic type of impaired blood circulation in the brain, he may be prompted for a permanent supportive therapy with a route of oral administration or intravenous administration of Mildronate.

It is important to point out that in such a state of ailment, one can independently choose the shortest way to maintain one's liking. Also, do not forget about how the body reacts to oral administration of the drug, whether there are pathologies or dysfunctions of the mucosal-intestinal tract.

It is possible, in certain situations, for example, if you are not sick to take a pill, otherwise you won’t get into the shell, it’s better to be on the inside of the tongue. Although it is possible to take drugs in tablets, it is more likely to win this type of therapy.

Chronic cerebrovascular accident. For the presence of such a patient, I will recommend that you administer Mildronate with an internal injection of 500 milligrams, which requires 5 milliliters. The validity of such therapy becomes from 14 to 21 days. Repetition of the likuvalny course can be doubled or tripled on the river, which is the indication.

Dishormonal myocardial dystrophy. Similar pathological camp, which are accompanied by obvious pain sensations at the heart, leading to the jubilation of Mildronate by the way of the internal introduction of the medical treatment. It is shown dosing in the amount of 500 to 1000 mg per dose, which requires 5 or 10 ml per day, once for 24 years.

As a way to beat the lure of staging the internal language injections, then inject 500 milligrams (65 milliliters apart) for the long haul. As a result, the course of therapy in an indirect way has already ended, but non-receiving, painful symptoms in the heart did not deplete the patient, who would be indicated by taking Mildronate tablets for 12 days.

Rozumov and physical adventure, postoperative rehabilitation. The medicinal product can be taken in tablet form orally, or it can be used for intravenous, intravenous administration.

The patient is to blame for the way in which the drug is taken, since it is not the fault of the person to grow on their own, the next step is to seek medical help. Taking drugs in the form of tablets is impossible in situations, if the drugs are not conquered or are traded by the intestinal tract, or a low therapeutic effect is expected.

With the introduction of Mildronate intravenously or internally, dosing is indicated, which requires 500 milligrams of dobi in one go, or 250 milligrams of doby per doby. The duration of therapy should be established within 10 to 14 days.

As a medical indication, it is necessary to repeat the course treatment with Mildronate, proteo not earlier, no later than a day after the introduction of the remaining injection.

Alcoholism chronic form. The introduction of medical care is carried out internally only if there is a clear lesion of the nervous system in a patient. At this rate, a dose of 500 milligrams (5 milliliters each) is recommended for one day (maximum 10 days).

Illness of the vessels of the fundus of the eye and dystrophy of the sitkivka of the eye. Likarskiy zasіb is administered parabulbarno in obsyazі, scho vіdpovіdaє 500 mlіg (5 mlіlіtrіv rozchin) once per harvest. Trivality of jubilation to become the second time.

As it is necessary to use the ignition process, localization in the eyes, it is recommended to combine Mildronate with intravenous or intravenous administration of drugs in the hormonal corticosteroid group, for example, Prednisolone, Dexamethasone or Betamethasone.

If it is diagnosed with dystrophy of the eyes, then it is better to eat likarsky zasib with drugs that are directed at improving internal blood circulation.

Vagity

There are no sufficient medical data for anyone who takes Mildronat in any trimester of pregnancy. In order to prevent the possibility of a negative impact on the wine, the possibility of molding wines and other complications, doctors do not prescribe Mildronate during the wine-making period of a child.

Also, the doctors did not reveal that vcheni dosі, chi is seen as a medicinal plant at the same time from breast milk. Therefore, with the natural vigor of a child, as well as the need to go through the treatment with Mildronat, the little one should be transferred to a year with special piece sums.

especially vkazіvki

It is impossible to unequivocally respond to food, for some time you can safely go through the treatment with Mildronate. It’s all there for a day, individually and without middle ground in a diagnosed pathology, I will become a patient of that age. As shown by the instructions from the zastosuvannya, then on average the therapy does not exceed 60 days.

At the time of recognition of the medical treatment for prevention and prevention of the recurrence of any pathology, the validity of yoga should be close to 45 days. After a certain hour after the likuvannya, and also in advance of having consulted with a leading specialist, the doctor will mark the hour, if the next is to conduct a repeat course of the likuvannya.

The skin patient, which may have dysfunction or pathology of the liver, is guilty of being under special control by a medical doctor. In quiet situations, if an ailing person needs more than 30 days of rejoicing, it is important to regularly come to the doctor to look around.

Depending on the status of the pharmacy in that region, the availability of the medicinal product Mildronate will be considered. So, on average, the price for 40 pieces of tablets at a dose of 250 milligrams is about 300 rubles. For 10 ampoules, the price for injection at 10% concentration will cost between 420 rubles, and 60 capsules of Mildronate at a dosage of 500 milligrams will cost about 650 rubles.

Analogues

The most acceptable substitutes for Mildronate are: Meldonium (about 170 rubles for 10 ampoules), Cardionate (about 260 rubles for 5 ampoules), Idrinol (the most expensive analogue, the variety of which is in the range of 700 rubles for 5 ampoules).

It is important to understand that whether there is a medical zasib, the scheme of likuvannya, trivality, the dose and the analog are guilty of picking up more medical qualifications, which is relatively raising the outpatient card of the sick, yoga analysis and camp.

The instruction, presented on the site, is solely cognizant of the material, do not engage in self-deception, make your own diagnosis and sign of the drug. So you can no longer help your camp.

Mildronate (Meldonium - tablets, capsules, syrup, injections) - indications, instructions for use, analogues, recommendations, price

Name, form the release, warehouse and dosing of Mildronate

1. Capsules for implantation;

2. Syrup for implantation;

3. Designs for injections (internal, internal, and parabulbar).

• Methyl parahydroxybenzoate;
• Propylparahydroxybenzoate;
• propylene glycol;
• Sorbitol;
• Glycerin;
• Citric acid monohydrate;
• cherry essence;
• Barvnik Allura Red (E129);
• Barvnik Brilliant Black BN (E151);
• Purified water.

Capsules are dispensed in two doses - 250 mg each and 500 mg meldonium each. Mix the syrup with 250 mg of meldonium in 5 ml, so that the concentration is 50 mg / ml. And for injections, use 100 mg of meldonium in 1 ml (100 mg / ml).

Therapeutic treatment of Mildronate

• Cardioprotective action– zahist clitin of the heart from negative influxes and improvement of their living standards;
• Antianginal Dia- the vice of Klitin Mіocardis (for Rahuky Tsyogo Klіtin miocardials to be in the loud Kilkosti kisnyu, pushing the izhimi, and the vihinism of the pain, the frequency of an extent to the sbilshchi,
• Antihypoxic action- Change of negative impact to the deficiency of acid;
• Angioprotective action- protection and security of the integrity of the walls of ships;
• Tonіzuyucha dia.

In addition, Mildronate expands the blood-bearing capacity and normalizes the immune system, which increases the body's resistance to viral infections.

Mildronate - indication before congestion

• Ischemic disease of the heart (at the warehouse of the complex treatment);
• Angina pectoris (at the warehouse of complex lіkuvannya);
• Myocardial infarction (at the complex treatment warehouse);
• Chronic heart failure;
• pain in the heart with myocardial dystrophy;
• Dyshormonal cardiomyopathy (myocardiodystrophy);
• Functional impairment of the work of the cardiovascular system in children;
• Myocardial dystrophy in children;
• Neurocirculatory dystonia in children;
• Acute and chronic damage to the blood circulation of the brain (stroke, cerebrovascular insufficiency);
• Impaired blood flow in the eyes of the eye;
• Hemophthalmos (only for injections);
• Hemorrhages in the eyes (only rozchin for injections);
• thrombosis of the central vein of the sitka of the eye or її hilok (only for injections);
• Diabetic and hypertensive retinopathy (only for injections);
• Bronchial asthma (at the warehouse of complex therapy);
• chronic bronchitis (at the warehouse of complex therapy);
• Alcohol abstinence (at the warehouse of complex drinking);
• chronic alcoholism (at the warehouse of complex drinking);
• Low Rozumova and physical practice;
• Physical overvoltage and overvoltage;
• Postoperative period after any surgical intervention.

• For swedish inspiration after high advancement in training and magic;
• Overtraining;
• Low practice.

Mildronate - instructions from the application

Mildronate tablets (Mildronate 250, Mildronate 500) and syrup

• Have a teaspoon with 5 ml of radini;
• At the dessert spoon, put 10 ml of radish;
• At the far end of the spoon, 15 ml of rindine is placed.

So you can just take a spoon, so that you can take a lot of syrup, and pour yoga into it.

250 mg 5 ml

X \u003d 312.5 * 5 / 250 \u003d 6.25 ml.

Mildronate injections - instructions from the application

Dosing and rules for introducing Mildronate internally and internally

especially vkazіvki

Injected into the building keruvati mechanisms

Overdose

Treatment of an overdose of Mildronate is less symptomatic, directing to the use of severe manifestations and maintaining the normal functioning of the life of important organs.

Interaction with other medical care

• Antianginal diseases (Sustak, Nitrong, Betaloc, Kordanum, Trental, Dipiridamol, Riboxin and in.);
• Anticoagulants (Warfarin, Thrombostop toshko);
• Antiplatelet agents (Prostacyclin, Aspirin Cardio);
• Protiarrhythmic drugs (Adenocor, Amiodarone, Bretilat, Difenin, Kordaron, Moratsizin, Propanorm, Ritalmex, Rіtmіodarone and іn.);
• Sechoginnі preparations (Veroshpiron, Diakarb, Furosemid, etc.);
• Bronchodilators (Ventolin, Berotek toshcho).

Therefore, consider using Mildronate with Nitroglycerin, Nifedipine, alpha-blockers (Doxazosin, Setegis, Tulazine, etc.), antihypertensive drugs, and methods that expand the peripheral vessels (Traclir, Naniprus, Cormagnesin, etc.). tachycardia and a sharp decrease in arterial pressure.

Side effects

Contraindication to congestion

• Movement of the intracranial vice (on the aphids of the damaged venous flow or for the presence of intracranial puffiness);
• Vagity and breastfeeding (through lack of knowledge of total security);
• Increased sensitivity to allergic reactions to the components of tablets, syrup or other products;
• Vik young 12 years old.

In some instructions, it is stated that Mildronate is contraindicated for children under 18 years of age, however, similar terms are reinsurance from the side of the drug.

Meldonium - analogues

• Angiocardil rozchin for injections;
• Vasomag capsules and rozchin for injections;
• Idrinol rozchin for injections;
• Cardionate capsules and rozchin for injections;
• Meldonium capsules and rozchin for injections;
• Midolat capsules;
• Mіldrakor rozchin for injections (only in Ukraine);
• Mildrocard capsules (only in Belarus);
• Melfor capsules;
• Meditern capsules.

Analogues of Mildronate are the same preparations:

• Angiosil retard tablets;
• Antisten and Antisten MB tablets;
• Biosynth - lyophilizate for preparation of injections;
• Bravadin tablets;
• Valeocor-Q10 tablets;
• Vero-Trimetazidine tablets;
• Histochrome for injections;
• Deprenorm MB tablets;
• Dibikor tablets;
• Dynaton - rozchin for injections;
• Doppelherz Cardiovital tablets;
• Ezafosfinu liofilizat and ready-made rozchin;
• Іnozіє-F and Іnozіє-Eskom for injections;
• Carditrim tablets;
• Koraksan tablets;
• Peleti coronators;
• Kudevita capsules;
• Kudesan drops;
• Medarum 20 and Medarum MB tablets;
• Mexicor capsules and rozchin for injections;
• Metaguard tablets;
• Sodium adenosine triphosphate (ATP) for injections;
• Neoton lyophilizate for preparation of injections;
• Orocamag capsules;
• Pede rozchin for injection;
• Predizin tablets;
• Preductal and Preductal MB tablets;
• precard tablets;
• Ranex tablets;
• Riboxin capsules, tablets and injections;
• Rimecor and Rimecor MB tablets;
• Taufon tablets;
• Triducard tablets;
• Trimectal capsules;
• Trimectal MB tablets;
• Trimet tablets;
• Trimetazid tablets and capsules;
• Trimetazidine and Trimetazidine MB tablets;
• Trimitard MV tablets;
• Ubinone capsules;
• Fіrazin for injections;
• Phosphaden tablets and rozchin for injections;
• Ethoxydol tablets.

Instruction

trade name

MILDRONAT®

International non-proprietary name

Meldonij

Pharmaceutical form

Rozchin for injections 0.5 g/5 ml, 5 ml

warehouse

1 ampoule (5 ml each)

active speech- meldonium dihydrate 500 mg,

additional speech - water for injections.

Description

Prozora bezbarvna homeland

Pharmacotherapeutic group

Other preparations for curing heart disease. Meldonium.

ATX code C01EB22

Pharmacological authorities

Pharmacokinetics

Vsmoktuvannya

After intravenous administration of bagatorazovyh doses of meldonium, the maximum concentration (Cmax) reached 25.50±3.63 mcg/ml.

Bioavailability was increased in individuals with increased Cmax, area under the graph of changes in concentration per hour (AUC) and over the period of observation (t1/2), in patients with cirrhosis of the liver and in patients with severe deficiency. In case of intravenous congestion, AUC after a single and repeated doses of meldonium is considered. Qi results indicate the possibility of accumulation of meldonium in blood plasma.

Rozpodil

Meldonium from the bloodstream expands rapidly in tissues; may be high affinity to the fabric of the heart. Zv'yazok iz bіlkami plasma zbіlshuєtsya zaleno vіd an hour after zastosuvannya doses. Meldonium and yoga metabolism often cause placental barrier. There have been no further studies of meldonium in human mother's milk.

Metabolism

Meldonium smut rank is metabolized in the liver.

Vivedennya

In the presence of meldonium and its metabolites, a significant role is played by nirkov excretion. After a one-time intravenous infusion of 250 mg, 500 mg and 1000 mg doses of meldonium, the period of early administration of meldonium should be 5.56-6.55 years, the last period of administration - 15.34 years.

Particular groups of patients

Patients of a frail age

The dose of meldonium should be changed for older patients with impaired liver function or for those with increased bioavailability.

Patients with impaired function

For patients with weakened activity, if there is an increase in bioavailability, then change the dose. Due to the interaction of nirk reabsorption with meldonium and other metabolites (for example, 3-hydroxymeldonium) and carnitine, as a result of which nirk clearance of carnitine is increased. Daily direct injection of meldonium, gamma butyrobetaine (GBB) and meldonium/GBB combinations on the renin-angiotensin-aldosterone system.

Patients with impaired liver function

Patients with impaired liver function, which may increase bioavailability, should change the dose of meldonium. Changes in indications of the activity of the liver in people after the dosage of doses, which became 400-800 mg, did not bother. It is not possible to exclude the possibility of fat infiltration in liver cells.

Pediatric population

There is no data about the safety and effectiveness of meldonium ingestion in children and children up to 18 years of age, so meldonium ingestion in this group of patients is contraindicated.

Pharmacodynamics

Meldonium is a structural analogue of the carnitine precursor gamma butyrobetaine (GBB), which has one of the carbon atoms substitutions for a nitrogen atom. In the minds of the increased interest in meldonium, it is revitalizing between the delivery and the need for clitin in acid, the accumulation of toxic products in exchange in clitin, protecting them from harm; may also be a tonic infusion. As a result of this stagnation, the organism is gaining viability and victoriousness, and quickly replenishing energy reserves. Zavdyaks to the authorities of meldonium zastosovuyt for the exaltation of various disorders of the activity of the heart-vascular system, bleeding of the brain, as well as the promotion of physical and rozumova praceszdatnosti. As a result, a decrease in the concentration of carnitine increased the synthesis of HBB, which is energized by vasodilating powers. In times of severe ischemic myocardial ailment, meldonium improves the necrotic zone, a short rehabilitation period. In case of heart failure, it increases the shortness of the myocardium, increases tolerance to physical stress, reduces the frequency of attacks of angina pectoris. In case of acute and chronic ischemic disorders of cerebral hemorrhage, I improve blood circulation in the ischemic socket, apply redistribution of blood to the crust of the ischemic tubercle. In some cases, neurological disorders (after cerebral hemorrhage, operations on the brain, head injuries, past tick-borne encephalitis) positively influence the process of physical and intellectual functions in the period of contraction.

Indication before zastosuvannya

In complex therapy, in such cases:

disease of the heart and vascular system: stable angina pectoris, chronic heart failure (NYHA I-III functional class), cardiomyopathy, functional impairment of the heart and vascular system;

hostile and chronic ischemic disorders of cerebral circulation;

reduced efficiency, physical and psycho-emotional overload;

in the period of contraction after cerebrovascular disorders, head injuries and encephalitis.

Method of stosuvannya that dose

Internally. Zastosuvannya drug predbachaє special prigotovannya before the introduction.

In conjunction with a possible stimulating effect, it is recommended to stop the drug in the first half of the day.

Cardiovascular disease and cerebrovascular accident

At the warehouse of complex therapy, 500 mg-1000 mg per day intravenously (5-10 ml for injections of 0.5 g / 5 ml), taking the entire dose once or twice for 2 doses. The maximum additional dose is 1000 mg.

Reduced pratsezdatnіst, overvoltage and period of clothing

500 mg (5 ml) per day intravenously. The maximum additional dose is 500 mg.

Trivality to the course of likuvannya - 4-6 tizhniv.

The course of healing can be repeated 2-3 times per river.

Summer patients

Summer patients with liver diseases and the dose of meldonium should be changed.

Patients with impaired function of the nerves

If the drug is excreted into the body through nirk, for patients with disorders of the nirok from mild to moderate severity, they should take a lower dose of meldonium.

Patients with impaired liver function

Patients with liver damage from mild to moderate severity should stop at a lower dose of meldonium.

Pediatric population

There is no data about the safety and effectiveness of meldonium ingestion in children and children under the age of 18, so the ingestion of this drug is contraindicated for children and young adults.

Pobichna diya

Often

Allergic reactions (advanced sensitivity, allergic dermatitis, kropivyanka, angioedema, anaphylactic reaction)

Headaches

dyspepsia

Ridko

Destroyed, almost fearful, intrusive thoughts, devastated by sleep

Paresthesia, tremor, hypoesthesia, noise in the ears, vertigo, confusion, impaired walking, anterior stance, restlessness

Tachycardia/sinus tachycardia, atrial fibrillation, arrhythmia, indicative of breast discomfort/chest pain

Collapse of the arterial pressure, hypertensive crisis, hyperemia, blanching of the skeletal curves

Sore throat, cough, dyspnea, apnea

Dysgeusia (metal relish in the mouth), loss of appetite, nausea, vomiting, accumulation of gas, diarrhea, abdominal pain

Visipanya (global / macular / papular), stinging

Pain in the back, mild weakness, mild spasms

Pollakiuria

Severe weakness, tremor, asthenia, severe flare-up, visceral flare-up, flare-up, cold, hot, cold, cold

Electrocardiogram (ECG) findings, accelerated heart function, eosinophilia

Contraindication

Increased sensitivity to meldonium dihydrate

Severe liver and / or nirkov deficiency

Vagity and lactation period, through the day of data about clinical zastosuvanni drug during the whole period

Children's life up to 18 years old

Medical interaction

Meldonium can be used together with nitrates of prolonged diuresis and other antianginal measures for the treatment of stable angina pectoris, together with cardiac glycosides and diuretic measures for the treatment of heart failure.

Meldonium can be combined with anticoagulants, antiplatelet agents, antiarrhythmic drugs and drugs to improve microcirculation.

Meldonium can be used to treat other drugs that can prevent glyceryl trinitrate, nifedipine, beta-blockers, other hypotensive drugs and peripheral vasodilators.

In patients with chronic heart failure, which are taken overnight for a change in symptoms of meldonium and lisinopril, a positive result of combined therapy (vasodilatation of the head arteries, improvement of peripheral blood flow and vitality, change in psychological stress) was shown.

When meldonium was ingested in combination with orotic acid for the use of stool, causing ischemia / reperfusion, additional pharmacological action was suspected.

After a one-hour zastosuvannya Sorbifer that meldonium in patients with anemia, caused by a deficiency of saliva, by improving the storage of fatty acids in erythrocytes.

Meldonium helps to reduce pathological changes in the heart, caused by azidotimidine (AZT), and indirectly affects the reaction of oxidative stress, caused by AZT, which leads to dysfunction of mitochondria. The use of meldonium in combination with AZT or other drugs for the treatment of bloated immunodeficiency syndrome (SNID) positively contributes to the treatment of SNID.

In the test, use the reflex of jealousy, viklikanoї etanol, meldonium, changing sleepiness. Under the hour of the court, viklikanih pentylenetetrazole, it was established that the anti-sudominal meldonium was pronounced. In my opinion, when stopping before therapy with meldonium alpha2-adrenergic blocker, yohimbine at a dose of 2 mg/kg and the nitric oxide synthase (COA) inhibitor N-(G)-nitro-L-arginine at a dose of 10 mg/kg, antisudominal diabetes is blocked completely. meldonium.

An overdose of meldonium may exacerbate cardiotoxicity caused by cyclophosphamide.

Carnitine deficiency, which occurs when D-carnitine (pharmacologically inactive isomer)-meldonium is ingested, may exacerbate cardiotoxicity caused by ifosfamide.

Meldonium may cause a decrease in cardiotoxicity caused by indinavir and neurotoxicity caused by efavirenz.

especially vkazіvki

Patients chronic diseases livers and niroks in case of trivial zastosuvanni should be taken care of (the next control of the functions of the liver and / or nirok).

Peculiarities of injection of a medicinal preparation on the building of keruvatitransport means or potentially unsafe mechanisms

There is no evidence about the impact on the building of the building by means of transport and potentially unsafe mechanisms.

Overdose

There are no overdoses, the drug is low-toxic and does not mean unsafe side effects for a healthy patient.

In times of decreased blood pressure, head pain, confusion, tachycardia, severe weakness are possible. Likuvannya is more symptomatic.

In times of severe overdose, it is necessary to control the functions of the liver and liver.

The relationship between the drug and the hemodialysis proteins is not significant.

Release form and packaging

5 ml in ampoules from a barless fold, I hydrolytic class with a line or a speck of broken.

5 ampoules are placed next to the contour middle package of polyvinylchloride lining.

2 or 4 contour middle packs at a time with instructions for medical zastosuvannya sovereign and Russian language are placed near a box of cardboard.

Wash away the savings

Save at temperatures no higher than 25 °C.

Do not freeze Chi!

Take care of the place inaccessible to children!

The term saving

Do not stop following the completion of the term of applicability, indicated on the packaging.

Wash your permits from pharmacies

For the recipe

Vlasnik of registration certificate

AT "Grindeks". Vul. Krustpils, 53, Riga, LV-1057, Latvia

Virobnik

Addresses of the organization that accepts claims on the territory of the Republic of Kazakhstan regarding the quality of the product (goods):

Representative office of AT "Grindeks"

050010, m. Almaty, Dostik avenue, rіg st. Bogenbai batira, 34a/87a, office No. 1

t./f. 291-88-77, 291-13-84

ate mail: [email protected]

Attached files

817660521477976824_ua.doc	85 kb
505048371477977981_kz.doc	91 kb

Description up to date 09.03.2016

• Latin name: mildronate
• ATX code:С01ЄВ
• Dyucha speech: Meldonium (Meldonium)
• Virobnik: JSC "Grindeks", Latvia

warehouse

One hard gelatin capsule of Mildronate contains 250 or 500 mg Meldoniya it looks like dihydrate as an active component and additional speech: Amylum solani (potato starch), Silicii dioxydum colloidal (colloidal silicon dioxide), Calcium stearate (calcium stearate).

For the preparation of the gelatinous shell, vicorous gelatinum (gelatin) and Titanium dioxyde (titanium dioxide) are used.

In one ml retail for injections Mildronate 100 mg Meldoniya and water for injection as an additional component.

One tablet contains Mildronate 500 mg Meldoniya phosphate-like and additional components: Mannitum (E421; mannit), Povidonum K-29/32 (povidone K-29/32), Amylum solani (potato starch), Silicii dioxydum (silicon dioxide), Cellulose microcristalline (cellulose Magnesium stearate ( magnesium stearate).

Release form

The drug Mildronate is released by the virobnik in the form:

• translucent bezbarvny rozchin for іnєktsіy;
• hard gelatin capsules No. 1 and No. 2, filled with hygroscopic crystalline powder of white color. The powder, which is contained in capsules, has a slightly characteristic smell and licorice relish (the capsule itself has a neutral relish);
• tablets Mildronate Gx 500 mg (taste of the tablet is slightly sour).

Rozchin is available in 5 ml ampoules (500 mg/5 ml). One carton package contains: 2 medium packs with 5 ampoules of Mildronate in the skin and instructions for injecting the drug.

Capsules are packed in a blister, 10 pieces per dermal. In one cardboard pack there are 4 blisters and instructions for filling the drug.

Pharmacological activity

Meldonij - ce synthetic medicinal plant, which is similar to the drug with γ-butyrobetaine (GBB; speech, which is the precursor of hydroxytrimethylaminobutyric acid - natural vitamin-like speech, spores group B vitamins ).

Zgidno with Wikipedia, meldonium the buildings are characterized by the improvement and energy security of the client and vikoristovuetsya like:

• cardioprotective ;
• antihypoxic ;
• angioprotective ;
• antianginal zasib.

Mechanism dії Meldoniya administers a wide range of pharmacotherapeutic powers. The use of this drug will improve the efficiency, reduce the manifestation of mental, intellectual and physical overvoltage, activate weaving і humoral .

In patients who suffer from heart failure , pushing the force soon heart m'yaz , lowering the frequency heart attacks (attacks), as well as increasing the body's tolerance to physical challenges.

With hospitable ushkodzhenny myocardium zastosuvannya Meldoniya upovіlnyu utavlennja nekrotizirovannyh zones, shortening the period of rehabilitation, normalization of blood circulation in the cavity of the ischemic ushkodzhennya and redeployment of the blood to the measles of the ischemic case.

In the minds of promotion meldonium сприяє відновленню балансу між транспортом кисню в клітини та потребою клітин у ньому, перешкоджає накопиченню в клітинах продуктів клітинного обміну та токсичних речовин, захищає клітини та клітинні структури від пошкоджень, забезпечує швидку компенсацію організмом його енергетичних резервів та підтримання найбільш високої швидкості обмінних процесів.

Tonizuyuchi CNS , meldonium effectively fix the damage to the functional state somatic and vegetative (autonomous) influences of the nervous system , including the damage that accompanies withdrawal syndrome in patients who suffer from chronic alcoholism.

In addition, speech beneficially flows into the camp dystrophically changed ships of the sitkivka what allows you to stop yoga for exaltation vascular and dystrophic pathologies of the fundus .

Pharmacodynamics and pharmacokinetics

The action of the active language of the drug is directly related to the inhibition of the enzymatic activity of γ-butyrobetaine hydroxylase, which is the remaining enzyme in the lance reaction to synthesis.

Meldonij spray a decrease in the concentration of free, pereskodzhaє transport through clitin membranes fatty acids of a long-term lansyug, which prevent cumulation in cells of activated forms of non-oxidized fatty acids, which are similar acylcarnitine і acyl coenzyme .

In ischemic tissues, it restores the balance between sour transport and other sour sours, altering the disruption of adenosine triphosphate transport, activating immediately with cym glycolosis, which proceeds without additional sour sagging.

The result of a decrease in concentration carnitine є increase in the synthesis of the vasodilator γ-butyrobetaine.

After I take Mildronate tablets per os, what should I take in meldoniy Swidko vmoktuєtsya at the grass path. The drug is characterized sufficiently high pokanik bioavailability. The rest becomes about 78%.

concentration Meldoniya reach their maximum values ​​in a year or two after receiving. In the body meldonium metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid.

Not installed, what can meldonium seen in the milk of a woman who is good. To that, as a mother, it is indicated for the treatment of Mildronat, for the entire period of therapy it is necessary pripiniti .

Notes about Mildronat

Suggestions about Mildronate on the forums better positive. The unique mechanism of this drug allows you to widely apply it to solve problems the cardiovascular system , as well as zasіb, scho promotes practice in healthy people, yakі zaznayut parts of the physical and intellectual vanity.

І patients of cardiological experts, doctors, and athletes slander that Mildronate provokes a tonic effect. In the midst of the stagnation, the function of memory is reduced, the processes of mind are quickened, the sparseness of the ruins rises, the vibrancy and the degree of resistance to the body to the influx of unacceptable factors.

Advice from cardiologists confirm the data of numerical studies, as they showed that Mildronate whiskey in capsules and in the form of injections allows more and less nine times to reduce the incidence of repeated myocardial infarction .

Patients' opinions about Mildronate allow the growth of whiskers, that the drug is simply necessary for people, the activity of such effects is associated with increased pressures on the body, as well as during the period after the accidental alcohol abuse, pain and liver in the heart area, VSD and other pathologies cardiovascular system .

Average rating 4,8-5 out of 5 points.

Tim is not less, sometimes there are negative comments about Mildronat. It is important to remember that, as if it were some other medicinal product, Mildronat gives a good result only in that case, if the correct dose of that supplementary treatment is correctly selected (as it is necessary).

Price of Mildronate

The price of the drug on the Ukrainian market

The average price of Mildronate 250 mg tablets is UAH 214.1. The price of Mildronate ampoules, 5 ml, is UAH 383.95. Capsules 500 mg cost 323-325 UAH. for packing. Mildronate Gx sell at the average for 233-240 UAH.