What are loop and thiazide diuretics. Indication before zastosuvannya

Hello, friends, skilki w articles on those other topics we have already discussed with you, skilki cіkavih topics bumped, I thank you for your likes and comments, for the return call, for those who share their knowledge with the comments. Today, singsongly, there will be no less talk, but let's talk about a serious topic: "Diuretics: a list of drugs."

We have already talked about diuretics, but I’ll still guess what are the chemical and natural speeches of different structures, which can be used to speed up the establishment and the appearance of the sect of nirok. At the same time, salt is released from the section, helping to normalize the arterial pressure, change the pressure on the heart, and swell up. Diuretics are indicated for ill people who suffer from hypertension and heart failure.

The measles and shkoda of sechogin preparations

The positive power of diuretics is corrosed by athletes (and we don’t blame you, even so). Accepting sechoginn in front of the magicians, it is easier and faster for them to go ahead and sign the zayva vag. Women also won the data. The bodybuilders piece by piece znevodnyuyut organism in order to bring home that m'yazi looked richly embossed.

Ale, like everything else, it’s the two sides of the medal, the order is the scale, the sechoginn_ preparations can be wicked:

At the same time, not only sodium salts are excreted from the body, but also the color of speech, for example, potassium, not enough of what you know to the dryness of fatigue and expend strength;
It is taken up by natural calcium excretion, which sprays salts with salts;
As soon as possible, the cutting may be brought up to;
Diuretics reduce the increase in the level of "bad" cholesterol in the blood;
Sechoginnі drugs can be the cause of dysfunction of the state system in humans.

In order to avoid the negative effects of sechoginic preparations on the body, I raja you do not engage in self-advocacy, prote consult with a doctor and get better, as diuretics will come to you, in a way you can zastosovuvat, with which you can combine, so that you can reach the best

Classification of diuretics

Sechoginnі zasobi are subdivided into classification:

For an hour, there is a clear effect (for example, “Sechovin”, “Furosemide” to a large number of dib - “Spironolactone”, “Eplerenone”);
For the validity of the drug (up to 4 years, for example, "Etacrynic acid" up to 4 days "Chlortalidone");
Over the scale of injection (weakly - "Aldakton", "Triamteren", medium - "Hydrochlorothiazide", "Hygroton", strong preparations - "Lasiks", "Uregyt").

There are different types of diuretics, the main ones are seen in 4 different groups:

1) Saluretics - the group of sechogins is already large, it includes loop diuretics, carbonic anhydrase inhibitors, thiazide-like and thiazide preparations. Tablets and powders of the group are released under the following names:

Diacarb;
Furosemide;
Dehydratin;
Pruretanid;
Indapamed;
Likhtarik and In.

2) Osmotic preparations - they take a short time to normalize the plasmatic pressure. The stench is even more effective in cases of swelling of the leg, brain, peritonitis, glaucoma, opiosis, and poisoning with medications. Osmotic looking diuretics:

Sorbitol;
Manit;
Sechivin.

3) Potassium-sparing diuretics are indicated for hypertensive patients, with all their effectiveness in the removal of radish, the stench still allows potassium salts to be depleted in the body. Name the drugs in this group:

Amiloride;
Triamteron;
Spironolactone;
Aldactone;
Triamur.

4) Calcium-sparing diuretics - effective in osteoporosis, hypertension. Name the groups clearly, what should be prepared for those who do not get calcium from the homeland. These sechogins are indicated to everyone who suffers from an overworld preoccupation with the skeleton of the body and the fragility of the bones. Name the drug:

Pamid;
Arindap;
Indap;
Indiur;
Retapress;
Hygroton.

Natural seed production

Order from chemical, basic series natural products, scho to take stimulation of the introduction of rіdini from the body Systematically zastosuvannya tsikh produktіv, hoch i povіlnіshe, nizh with vikoristannyhіm_chіchnyh preparіvіv prote prizvede to a positive bazhany result.

Lemon juice is also an effective remedy for nabryakiv. Tsey sik is diluted with water and drunk for preventive and juvenile purposes.

Sik іz Crane is a Swedish seed product, which is a good antibacterial agent, which positively influences the dynamics of robotics, sechostate systems, and the transfer of potassium from the motherland.

The apple ocet helps the zavoi rіdini, without changing the rіvіnіuchi in the body. Most often, it’s like refueling before weeding vegetables.

Likewise, varto means a crane, a sprinkling, a great kulbaba. Infusions and extracts from tsikh herbs are okremo or in collections with natural diuretic methods.

Likewise, you should treat with natural diuretics varto more carefully, so as not to bring the body to a total drought.

Diuretics list of the most popular and most common vicarious products you now have, the principle of their wisdom, let's now discuss the specific types of sechoginic benefits, which are distinguished and in some purposes. I check your comments, share the article in social media, subscribe to the blog update. See you soon!

Tsikave

With respect Volodymyr Manerov

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A number of other representatives of the diseases, which call for an increase in the obligation of the cross, thiazides and thiazide-like diuretics, are vicarious not only in the light of the swelling, but also in the case of advanced systemic arterial pressure. Features pharmacological authorities tsієї grupi zumovlyuyut pomirny antiabryakovy and hypotensive effect, the development of which may be accompanied by the development of unsafe electrolytic disorders. About the sequence of memory when titrating doses of drugs.

How do you develop thiazide sechogins?

Thiazide diuretics produce an effect at the epithelium borders, which run through the distal tubules of the nephron. High osmotic activity is caused by sodium cations, which causes the development of swelling, including in case of hypertension (“sodium pulls water along with it”). Thiazide and thiazide-like diuretics inhibit (block) protein structures - channels that act as a bridge for sodium and chloranion transport. Z tsієї cause their other name - saluretics ("to bring salt"). The amount of sodium changes, the osmolarity of the plasma decreases - the folds regress and the central pressure on the bloodstream decreases.

A cream of natriuretic activity, thiazide diuretics may have little effect on inhibition of the carbonic anhydrase enzyme. This effect is manifested by changes in phosphate anion and bicarbonate. Trivale vykoristannya preparations in thiazide sechoginic groups to lead to a weakening of the m'yazovy component of arterioles (resistive bed). Therefore, cardiologists use thiazide-like diuretics in the treatment of hypertension in combination with the main antihypertensive drugs.

Influencing calcium reabsorption (blood soaking), the drug is successful in case of adversarial osteoporosis, calcium nephrolithiasis. It is important that after pouring into the channels, to carry out calcium cations, reducing the remodeling of the vessels.

Nebazhany phenomena that intermeddle with drug overdose, associated with a uricemic effect (increased concentration of secic acid), leading to carbohydrate metabolism (hyperglycemia). It is possible to change the lipid profile of the sirowort (increases the amount of lipoprotein in low cholesterol).

Thiazide-like sechogens may have the same points of congestion, inhibition of the activity of the enzyme carbonic anhydrase. Other effects yourself. Vіdminnіst polagaє vіdminnostі khіmіchnoї budovi; Functional characteristics are similar.

Preparations and stosuvannya

The head drug of the middle thiazide diuretics is Chlortiazide (Hydrochlorothiazide). Chlortalidone, Indapamide, Xipamide lie before thiazide-like drugs. Currently, anonymous analog drugs (“generics”) are also registered.

Indications for using saluretics:

Relief of the swelling syndrome in nephrotic syndrome. Efficiency is low. Vikoristannya nabuvaє sensu when recognized in the warehouse of two-, and one-three-component diuretic therapy. Insufficient activity in nephrotic changes is explained by another mechanism: hypoproteinemia and oncotic swelling. Thiazide diuretics should be titrated against the improvement of the possibility of electrolytic damage - hypokalemia, hyponatremia.
Swellings with cirrhotic damage to the liver. Therapy at the warehouse of the combined sechoginous treatment.
Arterial hypertension. It is true that it is used as monotherapy, especially for mild leaks (grade 2). The choice of the risk of thiazide-like drugs in the treatment of hypertension is being assessed by cardiologists through trial and error, a recent reduction in pressure. The low-dose regimen should ensure proper control of the AT numbers, the increase in doses is less true with more severe swelling.
Chronic insufficiency of the heart is evidently up to the European and Russian cardiological recommendations will require the recognition of saluretics. Chlortalidone can be antihypertensive with a duration of 3 deb. Indapamide and thiazide diuretics are used for doba. So stinks change the risk of hyperkalemia. Tse allow you to beat them every other day, or even later. Krim tsgogo, relaxing on the smooth m'yazovі clitiny vessels spray zastosuvannu preparatіv in hypertension and CHF.

Side effects and contraindications

Side effects, which are called preparations of this group, are associated with metabolic and electrolytic disorders, which are related to the mechanism of action.

Hypokalemia and її arrhythmogenic effect right up to asystole. Vymagaє vіdmini drug and correction in place of potassium serum.
Hyponatremia.
Atherogenic changes in plasma with a change to thrombosis. Corrected by taking statins.
Hyperuricemia with the development of gouty attacks in arthritis or attacks with urates. Administration of the drug causes regression of this process.
Impaired carbohydrate metabolism, especially in case of total admission to beta-blockers.

Of the side processes of drugs, a list of contraindications is logically formed:

gouty arthritis, nephropathy;
hypokalemia;
decreases in sodium;
vagіtnіst (especially nebazhane vikoristannya Іndapamide as the name of the vaccinated drug z diєyu on plіd); at the same time as taking Hypotiazid at the warehouse of the combined drug (without ACE inhibitors) is allowed;
allergic reaction.

Perevagi vikoristanny saluretikov

An unequivocal plus of the choice of drugs in this group is the presence of a dose-dependent effect (with the right pressure). For larger doses taken, the pressure is not proportionally reduced.
A lower stage of vessel remodeling (relaxation of the smooth lingual component of the vessel wall).
Good tolerability and high efficiency in case of vicariousness in combination with other faces. In the case of a flare-up syndrome of any genesis, among those with refractory ruptures, therapy with two or three sechoginal benefits is required, one of which is a saluretic. Hypertension is enjoyed both in monotherapy regimens with thiazide drugs, and in combination with two or three hypotensive drugs. The most effective treatment for the group is with angiotensin-converting enzyme inhibitors, sartans, calcium antagonists in various combinations.
Thiazide diuretics can be used in patients with simultaneous manifestations of CHF and arterial hypertension. In cured hypertension, thiazide-like drugs are successful, especially as it increases the pressure of hypernatremia and when this patient is weak to bloating.
With osteoporotic lesions of the cysts and chronic heart failure or hypertension, it is viable to use saluretics. The stinks increase the reabsorption of calcium cations, which will bring success in successful summer patients with an one-hour manifestation of cystic and cardiac pathology.
These are the reasons for thiazide and thiazide-like sechogens to stagnate for calcium nephrolithiasis.

The choice of the drug, its dosing and the frequency of taking it, means less drug. Do not independently take this group of drugs, if you do not know the peculiarities of metabolism and possible side effects, you can harm your health.

From a long time ago, the nutrition about the effectiveness of sechoginal preparations was a topic for a super-scholar of rich scientists. Deyakі negatively placed to such a group of likes through їх side activities on nirks. Others tried to find direct preparations, which only worked on a specific nephron, and the theory was also crushed into fluff. Be yakі preparati dіyut on the whole nephron.

In addition, as a development of medicine, having begun to take great tempi, a group of survivors developed wisnovok, which would be the most effective classifier of preparations for the mechanism of їхної ії. This is how the group of thiazide diuretics appeared.

What are thiazide diuretics?

As you can see, all sechoginn preparations and filthy injections are added to the salt in the body, which, at its core, complicates the work of the heart. Diuretics of the thiazide series are preparations for the aggravation of the seizure, as they do not surround the patient with salt intake, induce for a small heart failure.

The main effect of diuretics of the thiazide series in other fields is in the change in the secretion of calcium and the increase in sodium production in the nephron, which influences the whole process. This process allows you to increase the exchange of sodium for potassium, which will help you to overcome the rest.

As a rule, thiazide diuretics are prescribed for implantation, and they begin within 1-2 years. More and more surpluses are present after 12 periods of fasting therapy.

The mechanism of action of thiazide diuretics is not as important as that of loop diuretics, which essentially reduces their effectiveness at the hour. However, the very same sechogenous preparations can be used practically for all, Crimean patients with acute nic insufficiency. In the rest of the mood, the weak character of the remedy does not interfere with the factors that resist youma.

Power of drugs

Thiazide diuretics are called for in order to get rid of the disease of the cardiovascular system. Fallow in view of this class of drug, stench can be recognized for various heart conditions.

Let's take a look at the main power of diuretics in the case of juvenile illnesses below:

Diuretics of this type for the treatment of arterial hypertension zastosovuyutsya on the cob of their winemaking, and until today no analogue has been invented. Practically in all countries of the world, thiazide diuretics are the first line drugs for the treatment of hypertension.
The main directives of thiazide diuretics are to reduce the risk of heart disease, stroke or heart attack, and also prevent the development of heart failure.
Zastosuvannya diuretics in cases of various trips It is directly related to such a group of illnesses: congestion of the heart type, hepatic, nirk, congestion with trival administration of glucocorticoids. The main advances in this direction will be the acceptance of likіv at hospitable form nirk and heart failure, in this case, loop diuretics will be effective.
Prevention of stone-setting at nirkah in a way of changing the level of calcium introduced from the nirk, which reduces its production by the body, apparently calcium stones in the nirk do not settle down.
Treatment of nephrogenic non cerebrodiabetes in a way to reduce the volume of blood, which circulates, which in one's own line leads to a stronger draw of water in the tubules of the nephron.

List of drugs

In pharmacies, it is possible to use a large number of sechovivid licions of a different type at a time.

Before that, how virushiti for a purchase, why categorically do not work without the recommendation of a doctor, varto z'yasuvati, what can be considered for thiazide diuretics?

Indication before zastosuvannya

The mechanism of diuretic thiazide diuretics affects their main medical indications:

body problems that blame the development of heart failure, liver cirrhosis and nephrotic syndrome;
hypertension;
nirkovokam'yana ailment.

Contraindication

When I take thiazide diuretics, remember that if you get sick, if you get sick, the drug is not recommended, but in some cases it is contraindicated.

The main ailments, for which vikoristovuvaty such medicines are contraindicated:

Gout as a result of the damage to metabolic processes, and therefore, to speed up the development of the disease is also to speed up;
Hyperuricemia- ailment, with a certain amount of sechoic acid exceeding the norm. With such an ailment, the accelerated elimination of the rіdini from the body will increase the concentration of sechoic acid.
Hypokalemia, hyponatremia- Lack of potassium and sodium in the body. With an increase in diuresis of the rіdini, more and more potassium or sodium will be introduced.
Hypercalcemia- contains calcium in the body exceeding the norm, the preparations can lead to calcification of stones in nirkah, which will strengthen the siege of the ailment.
Nirkov and liver failure in hostile forms, є direct contraindications before taking diuretics. Nirks simply do not run into the great flow of rіdini.
Addison's ailment- bilateral inflammation of the measles of the epidermis, as if interrupting the production of corticosteroids.

How to stop?

Advantages and shortcomings of thiazide diuretics

All medicines have side effects, advantages and disadvantages. To better understand the process of healing, which is a kind of prescription by a doctor, and to avoid side effects of varto rose in all the nuances of taking diuretics.

Perevaga: thiazide diuretics are sparing sechoginnimi preparations. As a rule, the very same faces are prescribed to patients, as there may be little relief in the robotic nirok, liver and other organs. Loop and other diuretics are contraindicated for use in these depressions.

Nedolik: this type of diuretic is already weak clinical pharmacology, and the patient can undergo a long course of complex management of hypertension. For the help of loop diuretics, you can speed up the process, but not all indications resist.

Variety of preparations

The fallow in the form of a drug and the dosage of fluent speech can be changed.

Let's look at a table of common prices for drugs and a number of thiazide diuretics:

Visnovok to tsієї statti є a short riddle about everything described above:

Diuretics thiazide series indicated for treatment of cardiovascular hypertension.
Їх osoblivistu є weakly developed, like, in one way, they don’t let nirks and other organs get overwhelmed, but in another, uppovilnyu process of likuvannya, like you can stretch out on a sprat of tizhnivs.
The main contraindications for treatment with thiazide diuretics є nirkova and heart failure.
Take it on your own such a preparation is not possible, because having poured into the work of the whole organism, it can be clearly controlled by the doctor.
Come to the preparation row it is possible in a skin chemist's office until the appointment of a doctor. Before going to the pharmacy, clarify the analogues of the drug, which are suitable for treating your form of ailment. It is necessary for this, so that from a number of options you can choose the one that suits you for the price and dosing.
Don't forget it too what is cheaper is not good, vtim, like the road. It is important to read the instructions carefully.
Never change the drug on yoga is an analogue of independent that for the proposition of a pharmacist. The rest may not know about your other illnesses and help the body become.
Be sure to listen until its self-confidence pіd hour zastosuvannya medchnical preparations. If the faces do not fit, the organism will react and give you reason.

Loop diuretics are the most potent diuretics among the most commonly used in clinical practice. Most often, loop diuretics zastosovutsya with exuberant infusions of various trips.

All loop diuretics, cream of ethacrynic acid, for chemical budovaya and sulfonamides.

Chemical structure of loop diuretics

List of drugs in Europe

In Europe, such loop diuretics are more widespread:

Bumex generic: bumetanide;
Edecrin generic: ethacrynic acid;
Demadex generic: torsemide;
Lasix generic: furosemide;
Sodium Edecrin Generic: ethacrynic acid.

List of drugs in Russia and Belarus

The most widely used loop diuretics:

Britomar (oral tablets)
Bufenox (oral tablets)
Bufenox injectable 0.025% (injectable)
Dover (oral tablets)
Laziks (Razchin for infusions)
Lasix (oral tablets)
Furosemide (Rozchin for intravenous and intravenous administration)
Furosemide (Razchin for injections)
Furosemide (Substance)
Furosemide (Substance-powder)
Furosemide (oral tablets)
Furosemide Lannacher (Razchin for injections)
Furosemide Lannacher (oral tablets)

Order of preparations

Irrespective of the appearance of other loop diuretics, the most popular speech group is being abandoned (lasix). Etacrynic acid is less effective, lower furosemide (especially in the case of impaired function of the nirok) and the most toxic of conventional loop diuretics. For example, the risk of ototoxicity is greater for her, lower for furosemide. Therefore, you won’t win for all the speeches of this group, call out - only in case of a patient’s allergy to other loops and thiazide diuretics (because you won’t take revenge on the sulfanilamide group). Bumetanide and torsemide (torasemide) are treated as furosemide with a strong and (torsemide) trivial effect.

Indication for ingestion of loop diuretics.

Loop diuretics are used in medicine mainly for the treatment of hypertension and the onset of various walks, often with congestive heart failure or circulatory failure.

Loop diuretics zastosovuyutsya with:

ruptures of various strokes (hepatic, cardiac and especially nirk), for example, in cases of ruptures due to heart failure, cirrhosis of the liver, nirkovoy insufficiency and nephrotic syndrome;
in acute nirkov insufficiency - increase nirkov blood circulation and stimulate blood flow in case of anuria (sickness);
hypercalcemia (intensely remove calcium from the body);
for forced diuresis in case of ailments with various chemical speeches, including faces;
loop diuretics are used for emergency help in case of swelling of the leg and swelling of the brain;
in case of arterial hypertension - only more short thiazide diuretics are prescribed in case of severe heart failure, in other cases through trivalium.

A systematic review by the Cochrane Hypertension group evaluating the antihypertensive effects of loop diuretics, showing only a marginal reduction in blood pressure compared to placebo. Looking back at the need for more randomized control testing.

Pharmacokinetics of loop diuretics

Loop diuretics are often, or less often, soaked in the mucosal-intestinal tract and are easily excreted from the body. For example, the bioavailability of furosemide when taken internally is close to 60%. Torsemide is record-breakingly fast (two to three times faster than furosemide) soaked in the intestinal tract. Most of the loop diuretics occur in apparently metabolites (for example, furosemide binds to glucuronic acid in nirks, bumetanide metabolizes in the liver). When injected through the mouth, when injected into a vein, the effect of loop diuretics is rather quick, but short-lived.

The most common loop diuretic - torsemide - 2 times more, less furosemide (this is the best among the group of loop diuretics for the treatment of hypertension).

Loop diuretics are applied to the Na-K-2Cl symporter (carrier) in the luminal part of the tubular epithelium of the ventral part of the loop of Henle. Lastly, the galvanization of the joint transport of Na, K, Cl. The blockade of chlorine transport reduces the electrochemical gradient of the increase in the surface of the epithelial membranes to the nephron and, as a result, galmuic reabsorption of sodium.

Strong sechogenous activity is explained by the fact that the main part of sodium, and also water, is reabsorbed in the visceral part of the loop of Henle. Loop diuretics in a way of active secretion are consumed at the lumen of the proximal tubules and compete with secic acid for vision, which causes up to її obstruction and hypercuricemia.

Loop diuretics may have a secondary effect. The secondary effect of this group of preparations is the increase in prostaglandin volatility, which leads to the expansion of the vessels and the blood supply of blood. NHRIs block cyclooxygenase, as they take part in the synthesis of prostaglandins, so NHRIs may reduce the effectiveness of diuretics.

Zagalni side effects of loop diuretics:

hypovolemia,
hypokalemia (it sharply increases the toxicity of cardiac glycosides),
hyponatremia,
hyperuricemia (may provoke an attack of gout),
hypocalcemia,
hyperglycemia,
hypomagnesia - magnesium intake is important possible reason pseudogout vinification (chondrocalcinosis),
zamorochennya,
indiscretion,
hypotension.

Rіdkіsnі side effects of loop diuretics:

dyslipidemia,
increase in the concentration of gray-wool creatinine,
hypocalcemia,
seep.

Ototoxicity is a serious, but rare side effect of loop diuretics. There may be a noise in the winds and confusion, but in serious depressions it can lead to deafness.

Crossover allergic reactions

Oskіlki takі petlovі dіuretiki furosemіd yak, i torasemіd bumetanіd tehnіchno Je sіrkovmіsnimi drugs (divіtsya The images in the loop structure rozdіlі hіmіchna dіuretikіv) was theoretically іsnuє rizik order scho patsієnti, chutlivі to sulfanіlamіdіv mozhut Buti chutlivі i to dіuretikіv loop. This risk is indicated at the tabs of the medicinal package. Tim is no less, in fact, a risk of cross-reactivity of nevidomy, and є deyak_ dzherela, yakі zaperechuyut the reason for such cross-reactivity. One report found that less than 10% of patients allergic to sulfanamide antibiotics may have cross-allergy to loop diuretics. However, the true cross-reactivity remains unclear, because the nature of such a reaction is different.

Etacrynic acid is the only drug of this class of sechoginic drugs, which is not sulfanilamide. However, there may be a clear aggravation, associated with toxic diarrhea on the intestinal tract.

Medical interactions

Loop diuretics when combined with aminoglycoside antibiotics sharply increase the risk of severe ototoxicity (non-reversible deafness); anticoagulants - increase the risk of bleeding; cardiac glycosides - increase the risk of arrhythmias; protidiabetic drugs from the group of similar sulfonic acid compounds - to increase the risk of hypoglycemia; NPZZ - change the effect of the rest. Loop diuretics increase the effect of propranolol and lithium preparations.

Loop diuretics and thiazides

Trivality of the effect in most loop diuretics (criminal torsemide) is significantly less, lower.

Loop diuretics may have a strong effect. A strong effect means an even higher risk of developing side effects (for example, in front of the disruption of the electrolyte balance and acid-lunar balance). Tse put loop diuretics at the program, it is a place before thiazide diuretics, if the need is not strong enough, then tryval diya (zocrema, with mild arterial hypertension).

Thiazide diuretics are more effective in lower loop diuretics in patients with normal NIR function, and loop diuretics are more effective in patients with impaired NIR function. do not spend activity at .

The plan is to heal the body in the form of salt and water, and even less the world will reduce the blood pressure. The reason for this is that in case of arterial hypertension, the stench does not increase the level of cholesterol in the blood and does not stimulate diabetes, on the advice of thiazide diuretics. However, loop diuretics have more side effects, and stinks are less effective in preventing aggravated hypertension and deaths.

Loop diuretics reduce the amount of sodium in the body, and calcium and magnesium. The preparations of this group can produce a strong dose and can lead to a significant decrease in the level of sodium in the blood, if taken at high doses. The stench can increase the amount of potassium in the place.

The negative power of loop diuretics reduces their effectiveness in treating arterial hypertension in the presence of thiazide diuretics.

Loop diuretics are practically not viable for "regular" treatment of hypertension, as the patient does not get concomitant illnesses. Therefore, if the stench is heard, it is not common (up to 6 years old), and you should call for more side effects, lower thiazide diuretics. Loop diuretics are prescribed for hypertensive patients, in those who have already developed heart or blood insufficiency, as well as manifestations of a congestive phenomenon, tobto nabryaki. With the intravenous introduction of loop diuretics, they call for a weakening of the vessels and in this way reduce the arterial pressure. To that їh zastosovuyut for usunennya hypertensive crises.

Active pharmacological features of loop diuretics

Note: *Ethacrynic acid vitriol in the USA is attributed to the high risk of ototoxicity (hearing impairment in the patient)

Loop diuretics may have significant side effects:

Decrease in hearing or sound in vuhah.
An increase in the level of sechoic acid in the blood, which in the course of time can cause gout to gout - sickly swollen globules, especially on the thumbs of the feet.
In people with increased sensitivity to sulfanamides, there may be a reaction to a number of drugs, including drugs for the treatment of diabetes, zocrema, such as diabenases and tolinases, as well as a number of antibiotics that can be used to avenge sirki.

In case of taking loop diuretics, it is necessary to control the totality of other drugs, which are taken at the same time. Deyakі podednannya can cause aggravation.

Antiseptic drugs: reduce the effectiveness of diuretics.
Rose blood: cry out sickness to the point of bleeding.
Digitalis: cause heart rhythm to be disrupted. Litіy: carrying that vomit.
Probenecid: reducing the effectiveness of sechoginal preparations.
: strongly improves heartbeat
Pokhіdnі sulfanilsechovini: low rіven tsukru in the blood.

behind chemical warehouse loop diuretics are administered one after one, for other drugs in a group of thiazide diuretics.

Loop diuretics are not safe to take in case of ailments of nirok and in case of sensitivity to that particular medication, or sulfa drugs. Do not varto take the preparations of this group during the period of pregnancy and the first hour of the year of breastfeeding - at the same time for selection drug consult with your doctor.

Loop diuretics were not common (up to 4-6 years), with a little torasemide and ethacrynic acid, the prevalence of them was 12 years. To that, as a victorious winner, then take them dotally 2 times for production.

Stopping loop diuretics in treating hypertensive crises

In patients with hypertensive crises in the middle of diuretics, there are looped sechogens (furosemide, torasemide), which are administered intravenously. Loop diuretics, in line with international recommendations, are no longer considered as the only drug for therapy in hypertensive crisis. At the same time, their internal infusion (in some cases - trivala internal infusion) is still recommended as one of the components of the combined exuberance. For example, in patients with nitrates, enalaprilat or beta-blockers in ailments with a hypertensive crisis, which were aggravated by severe coronary syndrome or a flare-up.

Intravenous administration of these loop diuretics can be used for the treatment of uncomplicated hypertensive crises, in combination with other forms of hypertension, which are administered orally or sublingually (under the tongue).

Doses of loop diuretics are given in the table, which can be taken for intravenous infusion (with the improvement of the level of the patient's disease).

Doses of loop diuretics that are vicarious during intravenous infusion

Note: * In case of increased infusion rate, I will add a new initial dose of the drug