Treatment of herpes type 2 in women. Disease and reproductive function. Chim unsafe genital herpes
Herpes type 2, like herpes simplex, is activated in women and people with a weakened immune system. Vіn can be triggered by such factors as: nervous stress, GRVI, alcohol abuse, chronic illness, and other causes. The herpes simplex virus, like HSV-2, develops through the manifestation of factors that provoke, and, from the other side, with the penetration into the body of other viral agents and pathogenic bacteria.
There is no glimpse of viral infection herpes simplex, and there are no vaccines at the present time, yakі would beat the virus infected by people. These vaccines have been tested in a number of great clinical trials, but the results can be further explored. Live attenuated vaccines are called for the prevention of such illnesses, like swine flu and windmill flu or shingles. Vaccination is not to be taken lightly, or a weakened version of the virus, which leads to illness. Whenever weakened, the virus was administered to mice with a rotten immune system, the mice became healthy.
Symptoms
HSV-2, like herpes simplex, is characterized by reddened skin curves and stinging. The HSV-2 virus spills onto the skin and mucous surfaces of the organs. Zocrema, in women, the area of \u200b\u200bpikhvi is affected, and in men, the urethra, scrotum, and the very same member. Quite often, the symptoms of inflammation appear on the inner side and stilt surfaces, as well as near the anal opening.
In addition, the virus was not detected in the nervous cells of these mice - the virus itself sounds there, escaping from the state of calm. Herpes simplex viruses are major global health problems. These epidemiological data slander the arrogant need for developing a safe and effective vaccine that protects both serotypes.
However, the results of clinical trials were such that they were disappointing. Neutralizing ABS was detected in serovats, but not tested in mucus membranes. These data indicate the need for collapsible immunogens to test for immunity against both serotypes. We evaluated the virus for safety, immunogenicity and efficacy of the vaccine against intravaginal infection in a model of skin scarification in different strains of mice.
After a few days, at home, the vinic inflamed papules are formed - a visip is characteristic of looking humpbacks, the stench is reborn into vesicles - resembling a clear-cut motherland of a serous type of bulb. Such hanging is the great gatherings that are made up of groups of small bulbs.
After 2-3 dobi, more vesicles burst, and on the їх місці vyrazki are formed, yakі then covered with dry mottles. The patient's camp improves less after 2-3 days, during this period it becomes more clinically inappropriate.
These data indicate that epithelial signs, which are suspected, may reflect local immunity, and not permanent replication of the virus. There are data to tell about those that the vaccine will overcome the vinification of latency. The mice were treated anteriorly with medroxyprogesterone in order to hormonally synchronize them to immunization and continued effectiveness. The vaccine protected 100% of the mice, yakі do not lie in the form of hormonal treatment. In addition, bears may be suspected for their susceptibility and immune responses to pathogens.
With the first manifestation of HSV-2, like herpes simplex, the following symptoms can provoke: severe weakness and illness in a person, and also show subfebrile temperature. Women and people with type 2 herpes often have more close inguinal lymph nodes. If a herpevirus infection recurs, then it is likely to have a mild illness. The hour of wellness improvement (remission) is changed by periods of acute herpes.
Therefore, we tested the vaccine for the effectiveness of a modified model of skin scarification against both serotypes. Passive tolerance of sirowoks from immunized mice protects native mice from intravaginal and skin infections. In mice, yakі otrimuvali dose of immune sirovatka one by one, were afraid of dying epithelial signs, but there was no neurological disease with 100% survival. Navpaki, mice, yakі took away T-clitins from immune mice and abos t-clitins from controls, ailments were given.
The introduction of the sirowort inside the chest also protected the mice from the skin diseases. Navpaki, mice, yaki took off the control sirovatka, developed severe epithelial and neurological diseases and infections with 100% lethality. Ninіshnє doslіdzhennya throwing a comment on this paradigm.
Zagostrennya ill
Early manifestations of type 2 herpes may show clear characteristic symptoms. The tendency to painful symptoms in the lesions of the zone and the frequency of hanging, as well as the triviality of the most inflamed, in the world of distant inflammation, like the herpes simplex, change. With this, in women and people, bulbils and moles do not settle, and recurrent manifestations of liver and tingling in the genital area. In some cases, HSV-2 can be accompanied by insignificant sightings of the stature of the body and difficult sechovipkannyam.
Qi results are reviewed according to results taken away from smaller subunits or attenuated by vaccine candidates. This rіven homolії to rob recombіnаtіyu arguably less malignant. The experiments were carried out with the award of the Albert Einstein College of Medicine from the medical review and review, Protocol no.
Immunization, passive transfer of antibodies and acceptance of T-cellin uptake
5 days prior to immunization, the mice were treated with a dose of 5 mg of medoxyprogesterone acetate. For receiving transmission of splenic T-cellin, immunized mice were selected 3 days after the dose increase. Before inoculation of the recipient mice, the purity and vitality of the cells were checked with the aid of flow cytometry and trypan blue preparation. Zagalom 3 × 10 6 T-clitin was transferred into the recipient mice internally through the tail.
In some women and people, a second infection with the HSV-2 virus may be possible without symptoms. Activity is manifest your own herpes infections lie down and become immune. Some ailments can, for all life, see a few phases of inflammation, others have to fight against it with skin pivroku. All lie down in the form of weakening of the dead forces of the body.
Epithelial infection for intravaginal infections was assessed by the onset of erythema, erythema, hair loss, erythema, swelling, important swelling, hair loss, morbidity, severe cases, multiple injuries and death. Neurological ailment for intravaginal infection was assessed by the onset of the following rank: slashing, slashing and constipation, paresis on the back end, paralysis of the back end, final paralysis of the back end and death. The mice were euthanized with cancer on 3 or 4 and were assigned a score of 5 points on the next day for statistical analysis.
In the face of this illness, patients may develop severe intoxication, as well as a psychoemotional decline, a change in activity, depression, a decrease in efficiency and an increase in appetite.
Possibly folded
Infection with herpes simplex and especially the HSV-2 virus is a problem for the reproductive functions of women and men. In women in the period of vaccination, the first (primary) infection and a recurrence of contagion can be caused before the end of the day. Like herpes simplex, HSV-2 can provoke the development of a fetus in the womb or lead to death.
The mice were anesthetized with an additional 5 minutes of stretching, so that the viral inoculum was hanging. The mice were controlled for 14 days and evaluated for signs of illness. Misham, who was given euthanasia at 4 balls, was given the value of 5 on the next day. Clitini was fixed with 2% paraformaldehyde, stuffed with a crystal violet color, and the number of single plaques was marked as a number.
Antibody-deposit analysis of cellular cytotoxicity
The strains were observed for up to 21 days after a mature culture for a cytopathic effect under an hour of exchange with the skin medium for 2 days. Zrazki, yakі read three chi less copies, vvazhalis negative. editor's review; Likarnya Gori Sinai, USA. . The reviewers may be able to discuss the decision before the revision of the sheet.
The most common risk of infection of a possible baby in the womb of a woman is provoking active HSV-2 infection, without ulcers clinical manifestations. With caution, women often experienced recurrent genital herpes, there was an increase in the development of cancerous growths on the cervix of the uterus, and in men - oncological lesions of the anterior follicle.
Similarly, the opinion of the author will show only the main problems pointed out by the reviewers. Your article was visibly rated by Randy Shekman and three reviewers, one of whom served as guest review editor. Two of three reviewers, Susan Pierce and Andrew McMichael, were helpful in revealing the specialty.
Three reviewers were very positive about this manuscript. The authors may have opinions on six questions, violated by the reviewer No. 1. Do not rely on additional experiments. Nareshti, be kind, discuss food, reviewers No. 2 and No. No new experiments.
Celebration
In therapy for herpes type 2, vicorist is used in such a strategic way:
- blockade of reproduction of herpevirus;
- spryannya pokraschennya zagalnogo samoochuttya;
- correction of the immune system.
To effectively treat herpevirus infection, hospitable form and in the period of reactivation, stop anti-rus medical care, at the same time with the help of symptomatic therapy. In a successful course of visits, virostatics and interferon are also included. If patients are afraid of severe infections, for treatment, zastosovuyt internal injections of immunoglobulin.
Follow-up is important, innovative and crazy, kindly broken. Prote є deyaki problems, yakі require the respect of the authors. Although the vaccine is already effective, the immune response is not effective and a repeat immunization is necessary. The authors show the defense after a short interval of an hour. How long have you been immune?
It may affect the effectiveness of vaccines in humans. Authors can discuss. The authors are guilty of adding sickness and titri viruses. Follow-ups are being carried out to check the durability of the immune response in mice. We know that in the world, in the process of clinical trials, additional doses may be needed. The specific determinants of extinction are still unknown. Tse will be looked at in the future achievements.
Prevention
In the best way, I can protect against relapses, like herpes simplex, and HSV-2, which improves the immune functions of the human body and drastically affects the immune system. A healthy, normal way of life, proper food intake, as well as a change in stressful situations, allow for repeated manifestations of this virus.
Information about the article by that author
Let's take a look at alternative strategies for consumption. We allow that antibodies targeted to other viral antigens, such as glycoprotein, are susceptible to cross-infection. Tsі doslіdzhennya will be held at the future. We added a proposition that qi force on the reviewed discussion. Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, US Department of Pediatrics, Albert Einstein College of Medicine, New York, USA. Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, USA Medical Institute Howard Hughes, Albert Einstein College of Medicine, New York, USA.
National Institutes of Health
Howard Hughes Medical Institute.- Christopher Petro Thomas Jandl Nazanin Khajuenejad Betsy S Herold.
- Nataliya Chesenko Betsy S Herold.
- Thomas Jandl Nazanin Khajueynyad Betsy S Herold.
- Christopher Petro Angers Benard.
- Pablo A. Gonzalez Miami Sengupta.
In periods of remission, it is necessary to carry out the renewal of microflora in the empty intestines and the therapy of other inflammatory ailments. Patients are shown the infusion of immunostimulants, which are created on the basis of natural speech and natural components. At what stage is it possible to vaccinate for the formation of immune functions.
John Kim for help with experimental creatures. We would also like to thank Kyle Weiss, Jojern Schmitz and Birgit Koriot-Schmitz for re-reading this manuscript. The authors do not declare the existence of a financial conflict of interest. Experiments with creatures: it was carried out at the suvoriy vіdpovіdnosti to the recommendations of the Posіbnik z vikoristannya of laboratory creatures of the National Institutes of Health. All the creatures were processed to the point of commendation to the Albert Einstein College at the Institute for the Care of Creatures of that yogo victoria, Protocol no.
The vaccine is an effective way to treat herpes type 2. Vaughn with a sudden decrease in the possible occurrence of relapses and a short tolerance by the body of the onset of possible inflammations. After the introduction of vaccination at the stage of remission, patients are shown regular clinical exposure. At this stage, it is important to give the body a boost and prepare it for the onset of exultation.
The hostile necrosis of the sitkivka is deafened by a red eye, periorbital pain and a shattered starkness of the dawn. The results of the obstezhennia show episcleritis or scleritis, keratitis, vasculitis of the network, and necrosis with necrosis of the network. You can also call herpes simplex virus type 2, or you can also call herpes simplex type 1, which sounds like a cold sore wound around the mouth.
In some cases of genital herpes, the bulbs are similar to the ones in the genitals, but in other cases, the veins do not show the same symptoms, to those who are infected, they may not be transmitted to others. Sometimes in people who have genital herpes, only one sleep. Others have a lot of spalah, like less painful and short, lower first episode.
Controlling the preservation of remission is recommended to be carried out for 3 months, and for the number of relapses - a short period of time. So you need to come in, especially for women, at the hour of planning the vacancy of the chi її go. For certain groups of ailments, it is possible to continue treatment with immunomodulatory drugs and probiotics.
With proper and adequate attention, the prognosis for most patients is favorable.
If someone has become infected with the herpes virus, the veins are left at the body. Faces can alleviate the discomfort of spalling and surroundings, or else help them. Ale better to avoid herpes infection. Symptoms of herpes spalling begin with pain, tenderness or vermin in the genital area, and can also include fever and headache. On pihvі, penissi, scrotum, anusі, stegnah or sіdnitsyah bumps and fluff can appear. The blister is not uncommonly opened for the adoption of ill-tempered virazok, which can last up to 3 tizhniv.
Other symptoms may include: if you notice liver or urination; bіl in m'yazakh; and lower, swollen ulcers in the groin area. After a first herpes infection, the virus can be indolent without any symptoms. Ale the virus can re-activate later, to make it up to the night, like it doesn’t sound until the stench is at the first hour of sleep. The virus may tend to reactivate after some kind of stress, such as a cold, infection, hormonal changes, menstrual periods before the great testing at school.
Herpes simplex viruses type 1 and 2 have infected approximately 90% of the adult population of the planet. The herpes virus after infection penetrates into the nerve nodes, depriving them of all the life of a person. Like zahvoryuvannya herpes type 2 (genital herpes) in the old days. The breadth of this ailment from these feasts has become permanent. Official statistics on the spread of illness to dosit temple. Most of the population is carriers of the virus. The symptomatology of the disease manifests itself in less than 20% of infected people.
Ways of transmission
Genital herpes type 2 is transmitted more importantly by the way. Transfer zdіysnyuєtsya in ill people of a healthy person at state contacts of different species. Vin can be transmitted through vaginal unprotected sex, oral contact, and anal unprotected sex. In addition, it should be remembered that the use of a condom during contacts with an ill person significantly reduces the risk of transmission of infection, but does not exclude it again. The carrier of the virus is also potentially unsafe of its partner. Іnfikuvannya neobov'yazkovo vіdbudetsya, however, ymovirnіst tsgogo in contacts without a condom є dosit high.
A woman gets infected from a sick person more often than a person from a woman. Before that, one option for how type 2 herpes is transmitted is the way of transmission from a sick mother to a child. Imovirnist infection of the fetus occurs in the remaining trimester of pregnancy. With any significant risk of aggravation in a vaginal woman and herpes, as it is indicated for a child.
Genital herpes can be type 1. Infection with it occurs during oral sex. Just like a partner has on his lips for an hour of contact, it hangs, wine is a real threat. For the presence of a partner on the lips of herpes, oral contact was blocked from him. Human ailment can carry a threat of infection and at the time of the presence of symptoms of illness, proteo, in the hour of remission, oral contact with it is possible, and also from the infection of latex shrimp.
Herpes type 1 can be blamed on human organs for an hour of self-infection. As if in the guise of a new herpetic infection, due to the lack of hygiene rules, the infection is transmitted on the state of the body. So it’s self-infected by itself, or during oral sex with an ailing person, you can blame herpes on the lips of type 2.
Genital herpes along the butt route is transmitted rarely, protetically, for example, with vicarious one and the same conditions of special hygiene. The risk of self-infection is especially high in the period of active manifestation of herpes. Necessary relay dotrimannya rules of special hygiene.
Symptoms
Symptoms of herpes type 2 still appear immediately after infection. Genital herpes is most often seen with reduced immunity, which cannot cope with the infection on its own. Prote sound symptoms and blame less in 10-12% of ailments. It is most common to treat a long-term infection in the patient's body without symptoms.
The main signs of genital herpes are drooping, obstructed by a calamity motherland. Before the appearance of this visipu, there is a chervoninnya. After about a week, the bulbs, from which the visip is formed, burst. On їх mіstsі z'yavlyayutsya vyrazki, yakі then hustle and rage. After a period of up to 2 days, the hangings are covered with a healthy skin. Appearing to visipu is accompanied by strong sverbіny, almost liver and painful sensations.
Visipannya can show up for inner side stegon, on the outer organs, near the anal opening, on the ridges, at the crotch, in the slit, and in women, wind it at the pelvis in the cervix of the uterus. Whom will have an increase in inguinal lymph nodes. The ailing person often gets sickly self-consciously, he is afraid of an increase in temperature. In addition, at the hour of the sechoviperation, they can be guarded by incomprehensibility.
After the first manifestations of herpetic infection are blamed, the symptoms of being ill for a long time can be daily. When the form of illness is started, relapses can occur 2 times per month.
Soothing herpes
Genital herpes is not safe in its own way possible arrangements. Vin is a serious threat to health, both women and men. Herpes can be hostile to human organs, zocrema yogo brain. Ale, more than the worst type 2 herpes is the possibility of a complication in a vaginal woman or a fetus. In 20% of cases, herpes infection can be the cause of fetal incarceration or death.
In a newborn who is infected in the mother, herpes can cause serious illness. Infection can affect various organs, diseases neurological damage, and okremih vipadkah, genital herpes in children lead to a lethal result.
In humans, genital herpes leads to a decrease in macular immunity, which most often leads to the development of other infections of the sechostatic system. Herpes can become the cause of human infertility. Also, for cases of carrying out research, genital herpes can be a provocateur for the development of prostate cancer.
In women, genital herpes can be symptomless, which is often due to the daily occurrence of infection. Like in people, in women, genital herpes is a provocateur for the development of cervical cancer, especially in people infected with the papilloma virus.
Great significance may be due to the virus, so that the development is more complicated, and it is practically switched off with the right likuvanni ill.
Treatment of genital herpes
Treatment of herpes type 2 can be observed under the suvorim control of the doctor. Externally, the treatment of the virus is still impossible, prote, important, symptomatic treatment, as if it were manifesting infection. Antiviral chemotherapy is still the most effective glee. It is also important to boost immunity in tone, for which special preparations are needed.
